Birth weight and adult hypertension, diabetes mellitus, and obesity in US men
Birth weight and adult hypertension, diabetes mellitus, and obesity in US men
复制标题
DOI：
10.1161/01.cir.94.12.3246
复制
发表时间：
1996-12-15
期刊：
影响因子：
37.8
通讯作者：
Stampfer, MJ
中科院分区：
文献类型：
--
作者：
Curhan, GC;Willett, WC;Stampfer, MJ
背景 低出生体重与多种成人慢性疾病有关，包括高血压、糖尿病和肥胖。为了更准确地确定与出生体重相关的风险，需要在大型队列中进一步研究这些疾病，并提供各种危险因素的信息。方法和结果我们在 22 846 名美国男性队列中研究了出生体重与成人高血压累积发病率、非胰岛素依赖型糖尿病发病率和肥胖患病率之间的关系（卫生专业人员随访研究）。通过每两年邮寄一次的调查问卷收集出生体重、病史、家族史和其他因素。使用逻辑回归来检查出生体重与这些慢性成人疾病之间的关联。低出生体重与高血压和糖尿病风险增加有关；高出生体重与肥胖风险增加相关。与参考出生体重类别（7.0 至 8.4 磅）的男性相比，体重
Background Low birth weight has been associated with several chronic diseases in adults, including hypertension, diabetes mellitus, and obesity. Further study of these diseases in a large cohort with information on a wide variety of risk factors is essential to determine more precisely the risks associated with birth weight.Methods and Results We examined the relation between birth weight and cumulative incidence of adult hypertension, incidence of non-insulin-dependent diabetes mellitus, and prevalence of obesity in a cohort of 22 846 US men (Health Professionals Follow-up Study). Birth weights, medical histories, family histories, and other factors were collected by biennial mailed questionnaires. Logistic regression was used to examine the association between birth weight and these chronic adult diseases. Low birth weight was associated with an increased risk of hypertension and diabetes; high birth weight was associated with an increased risk of obesity. Compared with men in the referent birth weight category (7.0 to 8.4 lb), men who weighed