Cancer mortality in the European Union, 1970-2003, with a joinpoint analysis
Cancer mortality in the European Union, 1970-2003, with a joinpoint analysis
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DOI：
10.1093/annonc/mdm597
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发表时间：
2008-04-01
影响因子：
50.5
通讯作者：
La Vecchia, C.
中科院分区：
文献类型：
--
作者：
Bosetti, C.;Bertuccio, P.;La Vecchia, C.
背景：癌症死亡率在20世纪80年代末在欧盟达到顶峰，之后有所下降。材料和方法：我们对世界卫生组织提供的1970-2003年欧盟癌症死亡率数据进行了分析。结果：总体上，男性癌症死亡率自1988年以来趋于平稳，1993-2003年有所下降(年百分比变化，APC=-1.3%)。自20世纪70年代初以来，女性的比例一直在稳步下降。男性癌症死亡率的下降是由肺癌推动的，自20世纪80年代末以来一直保持稳定，此后有所下降(1997-2003年APC=2.7%)。其他与烟草有关的癌症，如口腔/咽喉、食道、喉和膀胱癌，以及结直肠癌(1992-2003年APC=-0.9%)和前列腺癌(1994-2003年APC=-1.0%)近期也出现下降。在女性中，乳腺癌死亡率自20世纪90年代初以来保持稳定，此后有所下降(1998-2003年APC=-1.0%)。在1970年至2003年期间，女性结直肠癌和子宫癌的死亡率下降，而在过去30年中，肺癌的女性死亡率上升(2001-2003年APC=4.6%)。在1970年至2003年期间，两种性别的胃癌和少数可治疗癌症的死亡率都有所下降。结论：这项对欧盟癌症死亡率的最新分析显示，近年来两种性别的死亡率都呈现出良好的模式。
Background: Cancer mortality peaked in the European Union (EU) in the late 1980s and declined thereafter.Materials and methods: We analyzed EU cancer mortality data provided by the World Health Organization in 1970-2003, using joinpoint analysis.Results: Overall, cancer mortality levelled off in men since 1988 and declined in 1993-2003 (annual percent change, APC = -1.3%). In women, a steady decline has been observed since the early 1970s. The decline in male cancer mortality has been driven by lung cancer, which levelled off since the late 1980s and declined thereafter (APC = 2.7% in 1997-2003). Recent decreases were also observed for other tobacco-related cancers, as oral cavity/pharynx, esophagus, larynx and bladder, as well as for colorectal (APC = -0.9% in 1992-2003) and prostate cancers (APC = -1.0% in 1994-2003). In women, breast cancer mortality levelled off since the early 1990s and declined thereafter (APC = -1.0% in 1998-2003). Female mortality declined through the period 1970-2003 for colorectal and uterine cancer, while it increased over the last three decades for lung cancer (APC = 4.6% in 2001-2003). In both sexes, mortality declined in 1970-2003 for stomach cancer and for a few cancers amenable to treatment.Conclusion: This update analysis of the mortality from cancer in the EU shows favorable patterns over recent years in both sexes.