Synthesis, structure, and evaluation of a β-cyclodextrin-artificial carbohydrate conjugate for use as a doxorubicin-carrying molecule
Synthesis, structure, and evaluation of a β-cyclodextrin-artificial carbohydrate conjugate for use as a doxorubicin-carrying molecule
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用作阿霉素携带分子的 β-环糊精-人工碳水化合物缀合物的合成、结构和评估
DOI：
10.1016/j.bmc.2015.12.030
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发表时间：
2016
影响因子：
3.5
通讯作者：
K. Hattori
中科院分区：
文献类型：
--
作者：
T. Yamanoi;Y. Oda;K. Katsuraya;T. Inazu;K. Hattori
本文报道了一种β-环糊精（β-CyD）衍生物的合成方法。并对其包合能力和结构进行了讨论。SPR分析显示，β-CyD偶联物对固定化阿霉素具有3.8 × 106 M − 1的高包合缔合值。核磁共振结构分析表明，其高包合能力是由于偶联物的苯环与阿霉素的A环通过π-π堆积作用形成包合物所致。
This paper describes the synthesis of a β-cyclodextrin (β-CyD) derivative conjugated with a C,C-glucopyranoside containing a benzene unit. Its doxorubicin-inclusion ability and structure are also discussed. SPR analysis revealed that the β-CyD conjugate had a high inclusion association value of 3.8 × 106M−1for immobilized doxorubicin. NMR structural analysis suggested that its high doxorubicin-inclusion ability was due to the formation of the inclusion complex as a result of the π–π stacking interaction between the benzene ring of the conjugate and the A ring of doxorubicin.