RISK-FACTORS FOR THE SYNDROME OF VENTRICULAR ENLARGEMENT WITH GAIT APRAXIA (IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS) - A CASE-CONTROL STUDY
RISK-FACTORS FOR THE SYNDROME OF VENTRICULAR ENLARGEMENT WITH GAIT APRAXIA (IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS) - A CASE-CONTROL STUDY
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DOI：
10.1136/jnnp.52.7.847
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发表时间：
1989-07-01
影响因子：
11
通讯作者：
LUGARESI, E
中科院分区：
文献类型：
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作者：
CASMIRO, M;DALESSANDRO, R;LUGARESI, E
为验证脑血管病危险因素与心室扩大伴步态失弛缓综合征（VEGAS）之间的关系，进行了一项病例对照研究。该综合征仅根据临床和CT标准定义;然而，它可能代表以步态障碍为初始症状的特发性正常压力脑积水患者。17例患者的年龄和性别与1例住院患者和2例一般人群对照组相匹配。在考虑的危险因素中，我们发现血管紧张素转换酶与高血压之间有显著的统计学关联（比值比= 3.14; p = 0.032），缺血性心脏病（比值比= 4.20; p = 0.013），ECG缺血性变化（比值比= 3.67; p = 0.029）、低HDL-胆固醇水平（比值比= 3.75; p = 0.028）和糖尿病（比值比= 6.00; p = 0.018）。我们的研究结果表明，脑血管疾病的危险因素可能在血管紧张素综合征的发展中发挥作用。
A case-control study was performed to verify the association between the risk factors for cerebrovascular disease and the syndrome of ventricular enlargement with gait aproxia (VEGAS). This syndrome was defined on the basis of clinical and CT criteria alone; however, it may be representative of patients with idiopathic normal pressure hydrocephalus in whom gait disturbance is the initial symptom. Seventeen patients were matched for age and sex with one hospitalised and two general population controls. Among the risk factors considered we found a significant statistical association between VEGAS and hypertension (odds ratio = 3.14; p = 0.032), ischaemic heart disease (odds ratio = 4.20; p = 0.013), ECG ischaemic changes (odds ratio = 3.67; p = 0.029), low HDL-cholesterol levels (odds ratio = 3.75; p = 0.028) and diabetes (odds ratio = 6.00; p = 0.018). Our findings indicate that risk factors for cerebrovascular disease may play a role in the development of VEGAS.