Chemical, physical, and biological properties of Pd(II), V(IV)O, and Ag(I) complexes of N3 tridentate pyridine-based Schiff base ligand
Chemical, physical, and biological properties of Pd(II), V(IV)O, and Ag(I) complexes of N3 tridentate pyridine-based Schiff base ligand
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DOI：
10.1080/00958972.2020.1842378
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发表时间：
2020-11-12
影响因子：
1.9
通讯作者：
Nafady, A.
中科院分区：
文献类型：
--
作者：
Abdel-Rahman, L. H.;Abu-Dief, A. M.;Nafady, A.
合成了一种新的N-3-三齿亚胺配体2，6-二乙酰基吡啶二苯腙（DAPH）（L）及其Pd（II）、V（IV）O和Ag（I）配合物，并通过元素分析、红外光谱、核磁共振、摩尔电导和磁化率等方法进行了表征。所获得的数据证实了Pd（II），Ag（I），和V（IV）O配合物的几何结构，分别为正方形平面，四面体，和扭曲的四方锥。使用最小抑菌浓度（MIC）来探测DAPH配体和金属络合物使用三种不同细菌的体外抗微生物活性。结果表明，PdDAPH复合物对大肠杆菌的毒力最高，MIC最低（1.25 μ g/mL）。此外，通过三种人癌细胞系，肝癌（HepG 2），乳腺癌（MCF-7），和结肠癌（HCT-116），所制备的复合物的细胞毒活性进行了评价。在所有测试的复合物中，PdDAPH在比参比药物长春碱更短的时间和更低的剂量下引起细胞活力的显著损失。还测量了所有复合物的抗氧化活性，并与维生素C进行了比较。对所制备的金属-DAPH螯合物与小牛胸腺DNA的相互作用进行了研究，结果表明，Pd（II）络合物与小牛胸腺DNA的相互作用最强，其结合常数为6.02 kcal mol（-1）。还研究了所有复合物的分子对接，PdDAPH是最有前途的化合物，由于其与葡萄糖转运蛋白（GLUT 1）酶的活性口袋轻松的疏水相互作用。总的来说，这项工作的综合结果清楚地表明，这些新化合物有望成为有效的抗生素和抗癌剂。
A new N-3-tridentate imine ligand, 2,6-diacetylpyridinediphenylhydrazone (DAPH) (L), and its Pd(II), V(IV)O, and Ag(I) complexes were synthesized and characterized via elemental analysis, FT-IR, NMR, molar conductance, and magnetic susceptibility measurements. The obtained data confirmed geometrical structures of Pd(II), Ag(I), and V(IV)O complexes as square planar, tetrahedral, and distorted square pyramidal, respectively. Minimum inhibitory concentrations (MIC) were used to probe in vitro antimicrobial activity of DAPH ligand and metal complexes using three different bacteria. Results revealed that PdDAPH complex exhibited the highest toxicity and lowest MIC (1.25 mu g/mL) toward Escherichia coli. Moreover, cytotoxic activity of the prepared complexes was evaluated via three human cancer cell lines, hepatic carcinoma (HepG2), breast carcinoma (MCF-7), and colon carcinoma (HCT-116). Among all tested complexes, PdDAPH caused a significant loss of cell viability in less time and lower dose than the reference drug vinblastine. Antioxidant activity was also measured for all complexes and compared to vitamin C. Probing the interaction of the prepared metal-DAPH chelates with calf-thymus DNA showed the Pd(II) complex displayed the strongest interaction, with a binding constant of 6.02 kcal mol(-1). Molecular docking was also investigated on all complexes, with PdDAPH being the most promising compound due to its facile hydrophobic interactions with the active pocket of glucose transporter (GLUT1) enzyme. Overall, the combined findings of this work clearly demonstrate that these new compounds hold promise as efficient antibiotic and anticancer agents.