A simple, rapid and sensitive method for the simultaneous determination of eighteen environmental phenols in human urine
A simple, rapid and sensitive method for the simultaneous determination of eighteen environmental phenols in human urine
复制标题
DOI：
10.1016/j.chemosphere.2021.130494
复制
发表时间：
2021-04-09
期刊：
影响因子：
8.8
通讯作者：
Zhang, Jun
中科院分区：
文献类型：
--
作者：
Ao, Junjie;Zhang, Qianlong;Zhang, Jun
环境酚类化合物是一类典型的内分泌干扰物，其对人体的潜在危害已引起人们的广泛关注。尿酚浓度可作为评估人体暴露的有效生物标志物。建立了液液萃取-高效液相色谱-串联质谱（LLE-MS/MS）同时测定人尿中18种环境酚类（6种对羟基苯甲酸酯类、7种双酚类、4种二苯甲酮类和三氯生类）的方法。优化后的液液萃取法节省了时间，且所需有机溶剂量少。仅提取0.2 mL尿样并进行分析。该方法线性范围为0.9925-0.9994，检出限（LOD）符合要求。
Environmental phenols are a typical group of endocrine disrupting compounds (EDCs) and have caused growing concerns upon the potential adverse effects on humans. Urinary concentrations of phenols can be used as valid biomarkers for the assessment of human exposure. A method was developed for the simultaneous determination of eighteen environmental phenols (six parabens, seven bisphenols, four benzophenones and triclosan) in human urine using liquid-liquid extraction (LLE) coupled to high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The optimized LLE was time saving and required low volumes of organic solvents. A volume of only 0.2 mL urine sample was extracted and analyzed. The method yielded good linearity (0.9925-0.9994) and satisfactory limit of detection (LOD) (