Phototriggered Spatially Controlled Out-of-Equilibrium Patterns of Peptide Nanofibers in a Self-Sorting Double Network Hydrogel
Phototriggered Spatially Controlled Out-of-Equilibrium Patterns of Peptide Nanofibers in a Self-Sorting Double Network Hydrogel
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DOI：
10.1021/jacs.1c09172
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发表时间：
2021-11-24
影响因子：
15
通讯作者：
Hamachi, Itaru
中科院分区：
文献类型：
--
作者：
Nakamura, Keisuke;Tanaka, Wataru;Hamachi, Itaru
扩散过程产生的不平衡模式在自然界中普遍存在，尽管它们尚未充分用于人造材料的设计。在这里，我们描述了在自排序双网络水凝胶中使用基于光响应肽的纳米纤维形成光触发不平衡图案。使用光掩模进行光照射，然后进行热孵育，诱导肽纳米纤维在空间上受控凝结。根据共焦图像和光谱分析，亚稳态纳米纤维在辐照区域发生光分解，其中热力学稳定的纳米纤维与来自未辐照区域的单体进行重构和凝结。这些超分子事件受到光和扩散的调节，以促进独特的非平衡图案的创建，包括来自单线光掩模的两条线和固定在水凝胶中的蛋白质的线图案。
Out-of-equilibrium patterns arising from diffusion processes are ubiquitous in nature, although they have not been fully exploited for the design of artificial materials. Here, we describe the formation of phototriggered out-of-equilibrium patterns using photoresponsive peptide-based nanofibers in a self-sorting double network hydrogel. Light irradiation using a photomask followed by thermal incubation induced the spatially controlled condensation of peptide nanofibers. According to confocal images and spectroscopic analyses, metastable nanofibers photodecomposed in the irradiated areas, where thermodynamically stable nanofibers reconstituted and condensed with a supply of monomers from the nonirradiated areas. These supramolecular events were regulated by light and diffusion to facilitate the creation of unique out-of-equilibrium patterns, including two lines from a one-line photomask and a line pattern of a protein immobilized in the hydrogel.