Discriminative stimulus functions of CNS sedative drugs assessed by drug versus drug discrimination procedures in gerbils.
Discriminative stimulus functions of CNS sedative drugs assessed by drug versus drug discrimination procedures in gerbils.
复制标题
通过沙鼠药物与药物辨别程序评估中枢神经系统镇静药物的辨别刺激功能。
DOI：
10.1007/s002130050502
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发表时间：
1998
影响因子：
3.4
通讯作者：
Swedberg,MD
中科院分区：
文献类型：
--
作者：
Järbe,TU;Swedberg,MD
本研究关注的是解剖出更广泛的药理学类别，如镇静/催眠药，其中泛化测试往往表明共享的刺激效应的药物之间的区别刺激属性的差异。为此，在一个两个选择，T-迷宫任务中，用沙鼠研究了三到五个剂量的利血平（CDP），氯甲噻唑（CMZ），乙醇（ETOH）和戊巴比妥（P-barb）的辨别刺激效应。当歧视的基础上存在与不存在的药物管理，获得歧视的速度增加剂量依赖性的所有四种药物与日志会话的标准是一个线性函数的对数剂量。所有四条线的斜率相似。然后检查基于不同剂量的训练药物的辨别力的获得。使用2：1的高剂量与低剂量比例。用CMZ、ETOH和P-barb开发了判别控制，但用CDP没有。在用盐水进行的测试中，总是选择与较低训练剂量相关的T-迷宫的一侧。然后训练沙鼠使用至少两种不同的剂量组合来区分两种药物。获得了CDP与CMZ、CDP与ETOH、CMZ与P-倒刺、CMZ与ETOH的分辨力。只有在建立额外的训练程序之后，才能获得不同剂量的CDP与P-倒刺的区分度，以便在区分训练期间P-倒刺剂量从低剂量逐渐增加到高剂量; CDP训练剂量在两个不同组的沙鼠中为20和30 mg/kg，并将P-倒钩的剂量增加2.5 mg/kg，直到巴比妥酸盐的最终剂量达到20 mg/kg。因此，尽管通常显示具有相似的刺激作用，但CNS镇静剂/催眠药的广泛药理学类别的成员仍然显示彼此可区分。使用非药物测试（媒介物）来评估药物对之间的刺激控制，当响应在两种训练条件下均匀分布时，涉及相等的控制。
This study is concerned with dissecting out differences in the discriminative stimulus attributes between drugs from broader pharmacological categories such as sedative/hypnotics where generalization tests often indicate shared stimulus effects. To this end, the discriminative stimulus effects of three to five doses of either chlordiazepoxide (CDP), chlormethiazole (CMZ), ethanol (ETOH), and pentobarbital (P-barb) were studied with gerbils in a two-choice, T-maze task. When the discrimination was based upon the presence versus the absence of drug administration, speed of acquiring the discrimination increased dose-dependently for all four drugs with log of sessions to criterion being a linear function of log dose. The slopes of all four lines were similar. The acquisition of a discrimination based on different doses of the training drug was then examined. A two-to-one ratio of high to low doses was used. Discriminative control developed with CMZ, ETOH, and P-barb, but not with CDP. The side of the T-maze that correlated with the lower training dose was always selected in tests with saline. Gerbils were then trained to discriminate between two drugs using at least two different dose combinations. The CDP versus CMZ, CDP versus ETOH, CMZ versus P-barb, CMZ versus ETOH discriminations were acquired. The CDP versus P-barb discrimination was obtained across doses only after an additional training procedure was instituted such that the P-barb dose was incremented gradually from low to higher doses during discrimination training; the CDP training doses were 20 and 30 mg/kg in two different groups of gerbils, respectively and the dose of P-barb was incremented by 2.5 mg/kg until the final dose of 20 mg/kg was reached with the barbiturate. Thus, although often shown to share similar stimulus effects, members of the broad pharmacological class of CNS sedatives/hypnotics nonetheless were shown to be discriminable from one another. Non-drug tests (vehicle) were used to assess stimulus control between pairs of drugs, equal control being implicated when responding was evenly distributed across the two training conditions.