A comparison of the effect of total intravenous anaesthesia with propofol and remifentanil and inhalational anaesthesia with isoflurane on the release of pro- and anti-inflammatory cytokines in patients undergoing open cholecystectomy
A comparison of the effect of total intravenous anaesthesia with propofol and remifentanil and inhalational anaesthesia with isoflurane on the release of pro- and anti-inflammatory cytokines in patients undergoing open cholecystectomy
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DOI：
10.1177/0310057x0803600113
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发表时间：
2008-01-01
影响因子：
1.5
通讯作者：
Wang, Y. L.
中科院分区：
文献类型：
--
作者：
Ke, J. J.;Zhan, J.;Wang, Y. L.
该研究的目的是调查两种麻醉技术（全静脉注射技术与吸入技术）对开腹胆囊切除术期间促炎和抗炎细胞因子水平变化的影响。 40 名 ASA PS I-II 接受开腹胆囊切除术的患者被随机分为两组。 R组采用丙泊酚、瑞芬太尼全凭静脉麻醉，F组采用异氟烷平衡吸入麻醉。术中及术后测定血浆肿瘤坏死因子-α（TNF-α）、白介素IL-6、白介素IL-10水平。两组促炎细胞因子（TNF-α、IL-6）和抗炎细胞因子（IL-10）浓度较诱导前均显着升高（P
The aim of the study was to investigate the effects of two anaesthetic techniques (total intravenous technique vs. inhalational technique) on changes in pro- and anti-inflammatory cytokine levels during open cholecystectomy. Forty ASA PS I-II patients undergoing open cholecystectomy were randomly assigned to two groups. Group R received total intravenous anaesthesia with propofol and remifentanil and group F received balanced inhalational anaesthesia with isoflurane. The plasma levels of tumour necrosis factor-alpha (TNF-alpha), interleukin IL-6 and interleukin IL-10 were measured during and after surgery.The pro-inflammatory cytokine levels (TNF-alpha and IL-6) and the anti-inflammatory cytokine (IL-10) showed a significant increase in their concentrations compared with pre-induction levels in both groups (P