Primary cutaneous cryptococcosis: A distinct clinical entity
Primary cutaneous cryptococcosis: A distinct clinical entity
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DOI：
10.1086/345956
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发表时间：
2003-02-01
影响因子：
11.8
通讯作者：
Lortholary, O
中科院分区：
文献类型：
--
作者：
Neuville, S;Dromer, F;Lortholary, O
新型隐球菌是一种被包裹的酵母菌，可引起免疫功能低下宿主的播散性脑膜炎。原发性皮肤隐球菌病（PCC）与继发于血源性播散的皮肤隐球菌病的存在一直存在争议。因此，我们回顾了法国国家登记处报告的与皮肤病变相关的隐球菌病病例。PCC患者（n = 28）与继发性皮肤隐球菌病（n = 80）或其他形式的疾病（n = 1866）在居住地区（主要是农村）、年龄（较大）、男女比例（接近1：1）和缺乏基础疾病方面存在显著差异。PCC的证据包括没有传播，主要是在无衣服区域出现单独的皮肤病变，表现为白斑或白斑，皮肤损伤史，参与户外活动或暴露于鸟粪，以及分离出C。新生儿血清型D因此，PCC是一种独特的流行病学和临床实体，即使对于免疫功能低下的宿主也具有良好的预后。
Cryptococcus neoformans is an encapsulated yeast responsible for disseminated meningitis in immunocompromised hosts. Controversies persist on the existence of primary cutaneous cryptococcosis (PCC) versus cutaneous cryptococcosis being only secondary to hematogenous dissemination. Thus, we reviewed cryptococcosis cases associated with skin lesions reported in the French National Registry. Patients with PCC (n = 28) differed significantly from those with secondary cutaneous cryptococcosis (n = 80) or other forms of the disease (n = 1866) by living area (mostly rural), age (older), ratio of men to women (similar to1: 1), and the lack of underlying disease. Evidence of PCC included the absence of dissemination and, predominantly, a solitary skin lesion on unclothed areas presenting as a whitlow or phlegmon, a history of skin injury, participation in outdoor activities, or exposure to bird droppings, and isolation of C. neoformans serotype D. Therefore, PCC is a distinct epidemiological and clinical entity with a favorable prognosis even for immunocompromised hosts.