Serum antibody decay in adults following natural respiratory syncytial virus infection
Serum antibody decay in adults following natural respiratory syncytial virus infection
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DOI：
10.1002/jmv.20724
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发表时间：
2006-11-01
影响因子：
12.7
通讯作者：
Walsh, Edward E.
中科院分区：
文献类型：
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作者：
Falsey, Ann R.;Singh, Harjot K.;Walsh, Edward E.
检查成人中RSV感染后的血清抗体衰减，以评价免疫应答的持久性。20例RSV感染受试者和10例保持RSV未感染的受试者在16-25个月内采集血样，通过微量中和试验和酶免疫测定法进行分析。感染受试者的平均滴度在感染后上升约8倍。抗体滴度的平均下降率为每月-0.20 log 2滴度，导致75%的受试者在1年时滴度下降>= 4倍。相比之下，未感染受试者的滴度相对稳定。成人自然RSV感染后血清抗体增强引起的部分免疫似乎是短暂的。
Serum antibody decay following RSV infection in adults was examined to evaluate the durability of the immune response. Twenty subjects with RSV infection and 10 subjects who remained RSV uninfected had blood samples obtained over 16-25 months analyzed by microneutralization assay and enzyme immunoassay. The mean titers of infected subjects rose approximately eightfold post-infection. The mean rate of antibody decline was -0.20 log 2 titer per month which led to a >= fourfold drop in titer in 75% of subjects at 1 year. In contrast, titers of uninfected subjects were relatively stable. The partial immunity resulting from a boost in serum antibody following natural RSV infection in adults appears to be short lived.