Increased amygdala activation during mania: A functional magnetic resonance imaging study
Increased amygdala activation during mania: A functional magnetic resonance imaging study
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DOI：
10.1176/appi.ajp.162.6.1211
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发表时间：
2005-06-01
影响因子：
17.7
通讯作者：
Cohen, MS
中科院分区：
文献类型：
--
作者：
Altshuler, L;Bookheimer, S;Cohen, MS
目的：研究躁狂症发作期间杏仁核的神经活动。方法：对9名躁狂症受试者和9名健康对照受试者进行功能性磁共振成像(FMRI)，同时执行一种激活杏仁核的神经心理学范式。结果：与对照组相比，躁狂症受试者左侧杏仁核激活显著增加，双侧眶前皮质激活减少。结论：杏仁核激活增加，眶前皮质激活减少。结论：躁狂症患者杏仁核激活增加，眶前皮质激活减少。这些大脑区域可能牵涉到涉及情感调节的紊乱。
Objective: This study sought to investigate neural activity in the amygdala during episodes of mania.Method: Nine manic subjects and nine healthy comparison subjects underwent functional magnetic resonance imaging ( fMRI) while performing a neuropsychological paradigm known to activate the amygdala. Subjects viewed faces displaying affect ( experimental task) and geometric forms (control task) and matched them to one of two simultaneously presented similar images.Results: Manic subjects had significantly increased activation in the left amygdala and reduced bilateral activation in the lateral orbitofrontal cortex relative to the comparison subjects.Conclusions: Increased activation in the amygdala and decreased activation in the orbitofrontal cortex may represent disruption of a specific neuroanatomic circuit involved in mania. These brain regions may be implicated in disorders involving regulation of affect.