Reduced Serum Concentration of CC16 Is Associated with Severity of Chronic Obstructive Pulmonary Disease and Contributes to the Diagnosis and Assessment of the Disease
Reduced Serum Concentration of CC16 Is Associated with Severity of Chronic Obstructive Pulmonary Disease and Contributes to the Diagnosis and Assessment of the Disease
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DOI：
10.2147/copd.s230323
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发表时间：
2020-01-01
影响因子：
2.8
通讯作者：
Liu, Hua
中科院分区：
文献类型：
--
作者：
Rong, Biaoxue;Fu, Tian;Liu, Hua
背景：本研究的目的是揭示血清Clara细胞分泌蛋白（CC16）浓度与稳定期慢性阻塞性肺疾病（COPD）临床参数的相关性。患者和方法：采用酶联免疫吸附试验（ELISA）测定血清CC16浓度。采用线性相关分析和多元线性回归分析血清CC16浓度与临床参数的相关性。采用受试者特征曲线（receiver operator characteristic curve， ROC）评价血清CC16对COPD鉴别诊断的敏感性和特异性。结果：与健康对照组相比，稳定期COPD患者血清CC16浓度明显下调（p < 0.05）。血清CC16降低与患者吸烟（p < 0.05）、GOLD评分（p < 0.005）、mMRC评分（p < 0.05）、病史（p < 0.05）呈负相关，与肺功能呈正相关（p < 0.05）。吸烟、FEV1/FVC值、COPD分级及mMRC评分均影响CC16浓度（p < 0.05）。CC16降低是肺功能恶化过程中的独立危险因素。血清CC16诊断COPD的敏感性和特异性分别为65.3%和75%。结论：血清CC16浓度降低与COPD病情进展相关，可作为COPD诊断和评估的指标之一。
Background: The aim of this study was to reveal the correlations between serum concentration of Clara cell secretory protein (CC16) and clinical parameters of stable chronic obstructive pulmonary disease (COPD).Patients and Methods: Serum concentration of CC16 was determined by enzyme-linked immunosorbent assay (ELISA). The correlations between serum concentration of CC16 and clinical parameters was performed by linear correlation analysis and multiple linear regression analysis. The sensitivity and specificity of serum CC16 for differential diagnosis of COPD were determined by receiver operator characteristic curve (ROC).Results: The serum concentration of CC16 was down-regulated in stable COPD patients compared with healthy control group (p < 0.05). The decreased serum CC16 was negatively related to smoking (p < 0.05), GOLD grading (p < 0.005), mMRC score (p < 0.05) and medical history (p < 0.05) of patients, but positively correlated with pulmonary function (p < 0.05). The smoking, FEV1/FVC values, COPD grading and mMRC scores all affected the concentration of CC16 (p < 0.05). The decreased CC16 was an independent risk factor in the process of deterioration of lung function. The sensitivity and specificity of serum CC16 for identifying COPD reached to 65.3% and 75%.Conclusion: Decreased serum concentration of CC16 correlated with the disease progression of COPD, suggesting that it can be used as an indicator contributing to the diagnosis and assessment of COPD.