Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology
Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology
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DOI：
10.1016/j.fertnstert.2012.06.021
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发表时间：
2012-09-01
影响因子：
6.7
通讯作者：
Devoto, Luigi
中科院分区：
文献类型：
--
作者：
Gonzalez-Ramos, Reinaldo;Defrere, Sylvie;Devoto, Luigi
目的：更新、分析、总结核因子κ B （nf - κ B）参与子宫内膜异位症病理生理的相关文献。设计:回顾。结果：核因子- kappab在人子宫内膜中被生理激活，表现出不同的活性。健康女性子宫内膜显示环状p65-DNA结合模式。这种循环模式在子宫内膜异位症患者的子宫内膜中发生了改变。核因子- kappab在腹膜子宫内膜异位症病变中基本激活，红色子宫内膜异位症病变中p65活性高于黑色子宫内膜异位症病变。体内和体外研究表明，NF-kappa B活性上调炎症和细胞增殖，下调细胞凋亡。在子宫内膜异位症患者盆腔中已发现铁超载，铁超载和氧化应激激活巨噬细胞中的nf - κ B，参与子宫内膜异位症相关的炎症反应。结论：子宫内膜异位症患者子宫内膜核因子- kappab激活异常可能解释了子宫内膜异位症相关的一些子宫内膜生物学改变。科学证据强烈表明，子宫内膜异位症细胞中NF-kappa B的活性刺激炎症和细胞增殖，抑制细胞凋亡，有利于子宫内膜异位症的发生和维持。子宫内膜异位症患者盆腔铁超载可能是慢性增强氧化应激和激活NF-kappa B的主要因素，有助于子宫内膜异位症的建立和生长。肥料(R) 2012；98: 520 - 8。(C) 2012年，美国生殖医学学会。)
Objective: To update, analyze, and summarize the literature concerning nuclear factor-kappaB (NF-kappa B) participation in endometriosis pathophysiology.Design: Review.Result(s): Nuclear factor-kappaB is physiologically activated in the human endometrium, showing variable activity. A cyclic p65-DNA binding pattern was shown in the endometrium of healthy women. This cyclic pattern was altered in the endometrium of patients with endometriosis. Nuclear factor-kappaB is basally activated in peritoneal endometriotic lesions, showing higher p65 activity in red endometriotic lesions than in black lesions. In vivo and in vitro studies show up-regulation of inflammation and cell proliferation and down-regulation of apoptosis by NF-kappa B activity. Iron overload has been shown in the pelvic cavity of endometriosis patients, and iron overload and oxidative stress activate NF-kappa B in macrophages, which have been shown to participate in the endometriosis-associated inflammatory reaction.Conclusion(s): Nuclear factor-kappaB activation dysregulation in the endometrium of endometriosis patients may explain some endometrial biological alterations associated with endometriosis. The scientific evidence strongly suggests that NF-kappa B activity in endometriotic cells stimulates inflammation and cell proliferation and inhibits apoptosis, favoring the development and maintenance of endometriosis. Iron overload in the pelvic cavity of endometriosis patients could be a main factor enhancing oxidative stress and activating NF-kappa B in a chronic manner, contributing to endometriosis establishment and growth. (Fertil Steril (R) 2012; 98: 520-8. (C) 2012 by American Society for Reproductive Medicine.)