Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila
Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila
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DOI：
10.1016/s0960-9822(98)70162-9
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发表时间：
1998-03-26
期刊：
影响因子：
9.2
通讯作者：
Arias, AM
中科院分区：
文献类型：
--
作者：
Klein, T;Couso, JP;Arias, AM
果蝇翅膀的发育和图案化依赖于以翅膀想象盘的前后(AN)轴和背腹(DV)轴为参照系的细胞群体之间的相互作用[1-3]，这些细胞群体中的每一个都产生了一个隔室--一组细胞的命运受到细胞谱系的限制，在其中，细胞通过‘选择器’基因的表达获得特定的身份[1，2，4]。例如，嵌入(En)和侵染(Inv)基因标记后间隔中的细胞，并调节一组细胞相互作用，这些细胞相互作用指导翅膀沿AP轴的模式和生长[1，2，4]。类似的情况也被认为存在于整个DV轴上，以及作为背部选择基因的无翅(AP)[5]，通过调节Serrate(Serrate)[6，7]和边缘(FNG)[8]的表达来调节细胞相互作用，在AP突变体中，翅膀是最后的[5，9]，在这里我们报告了这种表型可以通过Ser或Fng的异位表达来挽救，并且令人惊讶的是，所得到的翅膀同时具有背部和腹侧细胞的命运。
The development and patterning of the Drosophila wing relies on interactions between cell populations that have the anteroposterior (An) axis and dorsoventral (DV) axis of the wing imaginal disc as frames of reference [1-3], Each of these Cell populations gives rise to a compartment - a group of cells that have their fates restricted by cell lineage within which cells acquire specific identities through the expression of 'selector' genes [1,2,4]. The genes engrailed (en) and invected (inv), for example, label cells in the posterior compartment and mediate a set of cell interactions that direct the patterning and growth of the wing along the AP axis [1,2,4]. A similar situation has been proposed to exist across the DV axis, along with apterous (ap) as a dorsal selector gene [5], mediating cell interactions by regulating the expression of Serrate (Ser) [6,7] and fringe (fng) [8], In ap mutants, the wing is last [5,9], and here we report that this phenotype can be rescued by ectopic expression of either Ser or fng and that, surprisingly, the resulting wings have both dorsal and ventral cell fates.