Gill circulation: regulation of perfusion distribution and metabolism of regulatory molecules.
Gill circulation: regulation of perfusion distribution and metabolism of regulatory molecules.
复制标题
鳃循环：调节分子的灌注分布和代谢。
DOI：
--
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
K. Olson
中科院分区：
文献类型：
--
作者：
K. Olson
鱼鳃是鱼体内外环境之间的主要调节界面，各种神经内分泌、内分泌、旁分泌和自分泌信号协调和控制鳃的功能。这些信使中的许多也影响鳃血管阻力，并且它们反过来可能被鳃血管灭活（或激活）。很少有研究严格地解决如何流分布在鳃丝，其生理后果，或鳃激素代谢对鳃和系统稳态的影响。在大多数鱼类中，整个心输出量灌注动脉通路，这一网络可能占大多数被动和刺激诱导的血管阻力变化。广泛的鳃微循环与全身血管的串联排列也表明了血浆传播的信使以及外源性物质的高代谢能力。腺苷、精氨酸缩血管素（AVT）和内皮素（ET）是迄今为止发现的最有效的鳃收缩剂，它们都能减少鳃板层灌注。也许并不奇怪，它们也被鳃血管灭活。尽管乙酰胆碱介导的反应的生理相关性尚不清楚，但乙酰胆碱有利于翼层间脉管系统的灌注。血管紧张素、缓激肽、尾加压素、利钠肽、肾上腺素和一氧化氮在不同程度上具有血管活性，但它们对脑内血流的影响尚不清楚。如果形式适合功能，那么鳃的复杂血管解剖结构表明其他脊椎动物器官中无与伦比的调节复杂程度。解决这些问题在技术上具有挑战性，但无疑是有益的。
The fish gill is the primary regulatory interface between internal and external milieu and a variety of neurocrine, endocrine, paracrine, and autocrine signals coordinate and control gill functions. Many of these messengers also affect gill vascular resistance, and they, in turn, may be inactivated (or activated) by branchial vessels. Few studies have critically addressed how flow is distributed within the gill filament, the physiological consequences thereof, or the impact of gill hormone metabolism on gill and systemic homeostasis. In most fish, the entire cardiac output perfuses the arterioarterial pathway, and this network probably accounts for the majority of passive- and stimulus-induced changes in vascular resistance. The in-series arrangement of the extensive gill microcirculation with systemic vessels is also indicative of a high capacity for metabolism of plasma-borne messengers as well as xenobiotics. Adenosine, arginine vasotocin (AVT), and endothelin (ET) are the most potent gill constrictors identified to date, and all decrease lamellar perfusion. Perhaps not surprising, they are also inactivated by gill vessels. Acetylcholine favors perfusion of the alamellar filamental vasculature, although the physiological relevance of acetylcholine-mediated responses remains unclear. Angiotensin, bradykinin, urotensin, natriuretic peptides, prostaglandins, and nitric oxide are vasoactive to varying degrees, but their effects on intrafilamental blood flow are unknown. If form befits function, then the complex vascular anatomy of the gill suggests a level of regulatory sophistication unparalleled in other vertebrate organs. Resolution of these issues will be technically challenging but unquestionably rewarding.
大西洋盲鳗 Myxine glutinosa (Agnatha) 鳃中利钠肽受体的定位和特征。
DOI：
10.1242/jeb.198.1.117
发表时间：
1995
期刊：
The Journal of experimental biology
影响因子：
--
作者：
Toop,T;Donald,JA;Evans,DH
通讯作者：
Evans,DH
海鱼 Stenotomus chrysops (Scup) 中的花生四烯酸代谢和细胞色素 P450 1A 诱导剂的影响。
影响因子：
3.9
作者：
Schlezinger,JJ;Parker,C;Zeldin,DC;Stegeman,JJ
通讯作者：
Stegeman,JJ