The Murine Angiotensin II-Induced Abdominal Aortic Aneurysm Model: Rupture Risk and Inflammatory Progression Patterns.
The Murine Angiotensin II-Induced Abdominal Aortic Aneurysm Model: Rupture Risk and Inflammatory Progression Patterns.
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DOI：
10.3389/fphar.2010.00009
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发表时间：
2010
影响因子：
5.6
通讯作者：
Funk CD
中科院分区：
文献类型：
--
作者：
Cao RY;Amand T;Ford MD;Piomelli U;Funk CD
腹主动脉瘤（AAA）是体内最大动脉的扩大，定义为直径增加1.5倍。AAA在老年人群中很常见，每年有数千人死于其并发症。最常用的研究AAA发病机制的小鼠模型是血管紧张素II（Ang II）输注方法，通过渗透微泵输送28天。在这里，我们研究了主动脉破裂的部位特异性和发病，其特征在于三维（3D）图像和流动模式在开发AAA的超声成像，并检查巨噬细胞浸润的血管紧张素II模型使用65载脂蛋白E缺陷小鼠。主动脉破裂发生在16只小鼠（25%），在主动脉弓（44%）和肾上腺区域（56%）几乎一样普遍，在血管紧张素II输注后的前7天内最常见（12/16; 75%）。纵向超声筛查与组织学分析有很好的相关性，AAA体积显示与AAA严重程度指数有显著关系。主动脉夹层发生在血流模式改变之前，巨噬细胞浸润是AAA发生的一个显著特征。用新的疗法靶向AAA疾病的炎症成分将有望导致新的策略来减弱动脉瘤生长和主动脉破裂。
An abdominal aortic aneurysm (AAA) is an enlargement of the greatest artery in the body defined as an increase in diameter of 1.5-fold. AAAs are common in the elderly population and thousands die each year from their complications. The most commonly used mouse model to study the pathogenesis of AAA is the angiotensin II (Ang II) infusion method delivered via osmotic mini-pump for 28 days. Here, we studied the site-specificity and onset of aortic rupture, characterized three-dimensional (3D) images and flow patterns in developing AAAs by ultrasound imaging, and examined macrophage infiltration in the Ang II model using 65 apolipoprotein E-deficient mice. Aortic rupture occurred in 16 mice (25%) and was nearly as prevalent at the aortic arch (44%) as it was in the suprarenal region (56%) and was most common within the first 7 days after Ang II infusion (12 of 16; 75%). Longitudinal ultrasound screening was found to correlate nicely with histological analysis and AAA volume renderings showed a significant relationship with AAA severity index. Aortic dissection preceded altered flow patterns and macrophage infiltration was a prominent characteristic of developing AAAs. Targeting the inflammatory component of AAA disease with novel therapeutics will hopefully lead to new strategies to attenuate aneurysm growth and aortic rupture.
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影响因子：
3.8
作者：
Baek, Hyoungsu;Jayaraman, Mahesh V.;Karniadakis, George Em
通讯作者：
Karniadakis, George Em
影响因子：
37.8
作者：
King, Victoria L.;Lin, Alexander Y.;Gerszten, Robert E.
通讯作者：
Gerszten, Robert E.
影响因子：
3.9
作者：
Baek, H.;Jayaraman, M. V.;Karniadakis, G. E.
通讯作者：
Karniadakis, G. E.
DOI：
10.1016/j.prostaglandins.2007.03.005
发表时间：
2007-08-01
影响因子：
2.9
作者：
Cao, Richard Yang;Adams, Michael A.;Funk, Colin D.
通讯作者：
Funk, Colin D.
DOI：
10.1016/s0967-2109(02)00042-x
发表时间：
2002-08-01
期刊：
CARDIOVASCULAR SURGERY
影响因子：
--
作者：
Thompson, RW
通讯作者：
Thompson, RW