Aggression in male mice lacking functional estrogen receptor alpha.
Aggression in male mice lacking functional estrogen receptor alpha.
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DOI：
10.1037/0735-7044.117.1.38
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发表时间：
2003-02
影响因子：
1.9
通讯作者：
E. M. Scordalakes;E. Rissman
中科院分区：
文献类型：
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作者：
E. M. Scordalakes;E. Rissman
雌激素受体α敲除（ERaKO）的雄性小鼠无法表现出性行为。作者假设ERalphaKOs需要比野生型（WT）雄性更高的睾酮(T)浓度才能表现出交配行为。增加T刺激WT雄性的性行为和对雌性的偏好，但在ERalphaKOs中没有这样做。然而，T确实在ERaKOs中诱导了雌性定向攻击。在攻击试验中，小白鼠选择性地攻击经t处理的雄性入侵者。ERaKO居民对雌性入侵者、接受t疗法的雄性入侵者和接受雌激素疗法的雄性入侵者的攻击程度相同。与WT雄性相比，在直接接触前增加嗅觉线索的接触减少了ERalphaKO的总体攻击性，但没有导致ERalphaKO对雄性和雌性对手的不同攻击。研究结果表明，erα对于正常的社会行为至关重要，可能是通过处理化学调查线索，这是区分男性和女性所必需的。
Estrogen receptor alpha knockout (ERaKO) male mice fail to display sexual behavior. The authors hypothesized that ERalphaKOs require higher testosterone (T) concentrations than wild-type (WT) males to exhibit copulatory behavior. Increasing T stimulated sexual behavior and preference for females in WT males but failed to do so in ERalphaKOs. However, T did induce female-directed aggression in ERaKOs. In aggression tests, WT residents selectively attacked T-treated male intruders. ERaKO residents attacked female, T-treated male, and estrogen-treated male intruders equally. Increased access to olfactory cues prior to direct contact reduced overall aggression in ERalphaKO versus WT males but did not cause ERalphaKOs to differentially attack male and female opponents. Results suggest that ERalpha is essential for normal social behavior, perhaps via processing of chemoinvestigatory cues, which are required to discriminate males from females.