Evaluation of vascular function in apolipoprotein E knockout mice with angiotensin-dependent renovascular hypertension
Evaluation of vascular function in apolipoprotein E knockout mice with angiotensin-dependent renovascular hypertension
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DOI：
10.1161/01.hyp.0000182154.61862.52
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发表时间：
2005-10-01
期刊：
影响因子：
8.3
通讯作者：
Vasquez, EC
中科院分区：
文献类型：
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作者：
Arruda, RMP;Peotta, VA;Vasquez, EC
众所周知，内皮功能在动脉粥样硬化和动脉高血压中受损，并且血管紧张素是促成这两种病理生理学的重要因素。本研究的目的是评价高胆固醇血症/动脉粥样硬化模型、血管紧张素II依赖性双肾一夹（2K 1C）高血压模型以及两种情况共存时的血管功能。8周龄载脂蛋白E基因敲除（apoE; n=20）和C57 BL/6（C57; n=20）小鼠进行2K 1C或假手术，并在28天后进行研究。apoE-2K 1C和C57- 2K 1C的平均动脉压（126 +/- 3和128 +/- 3 mmHg）高于apoE-假手术组和C57-假手术组（分别为103 +/- 2和104 +/- 2 mmHg; P
It is known that the endothelial function is compromised in atherosclerosis and arterial hypertension and that angiotensin is an important factor contributing to both pathophysiologies. The aim of this study was to evaluate the vascular function in a hypercholesterolemia/atherosclerosis model, in the angiotensin II-dependent 2-kidney 1-clip (2K1C) hypertension model and when both conditions coexist. Eight-week-old apolipoprotein E knockout (apoE; n=20) and C57BL/6 (C57; n=20) mice underwent a 2K1C or sham operation and were studied 28 days later. Mean arterial pressure was higher in apoE-2KlC and C57-2K1C (126 +/- 3 and 128 +/- 3 min Hg) when compared with the apoE-Sham and C57-Sham (103 +/- 2 and 104 +/- 2 mm Hg, respectively; P