Associations between both legacy and alternative per- and polyfluoroalkyl substances and glucose-homeostasis: The Isomers of C8 health project in China
Associations between both legacy and alternative per- and polyfluoroalkyl substances and glucose-homeostasis: The Isomers of C8 health project in China
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传统和替代全氟烷基物质和多氟烷基物质与葡萄糖稳态之间的关联：中国 C8 健康项目的异构体
DOI：
10.1016/j.envint.2021.106913
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发表时间：
2022
影响因子：
11.8
通讯作者：
Guang-Hui D
中科院分区：
文献类型：
--
作者：
Yun-Ting Zhang;Mohammed Zeeshan;Fan Su;Zheng-Min Qian;Sarah Dee Geiger;Stephen Edward McMillin;Zhi-Bin Wang;Peng-Xin Dong;Yan-Qiu Ou;Shi-Min Xiong;Xu-Bo Shen;Pei-En Zhou;Bo-Yi Yang;Chu Chu;Qing-Qing Li;Xiao-Wen Zeng;Wen-Ru Feng;Yuan-Zhong Zhou;Guang-Hui D
背景关于传统的全氟烷基和多氟烷基物质（PFASs）与葡萄糖稳态的关系的流行病学研究仍然不一致。对PFAS替代品的了解是有限的，很少有研究报告PFAS和PFAS替代品的联合协会。（氯化全氟烷基醚磺酸，Cl-PFESA和全氟丁酸，PFBA）和两种传统PFAS（全氟辛酸、全氟辛酸和全氟辛烷磺酸，PFOS）与葡萄糖稳态标志物，并探讨联合协会的13个传统和替代PFASs与选定outcome.MethodsWe使用的横截面数据的1,038名成年人C8健康项目的异构体在中国。使用PFAS的自然三次样条广义线性模型，在单污染物模型中探索了PFAS和PFAS替代品与葡萄糖稳态的关系。贝叶斯核机器回归（BKMR）模型被应用于评估暴露和结果的联合关联。性别特异性分析也进行了评估效果modified.ResultsAfter调整混杂因素，遗产（全氟辛酸，全氟辛烷磺酸）和替代（氯-PFESAs和PFBA）PFASs与葡萄糖稳态标志物在单污染物模型呈正相关。例如，在整个研究人群中，6：2Cl-PFESA和全氟辛烷磺酸第95百分位数的空腹血糖相对于阈值的95%置信区间估计变化分别为0.90（95%置信区间：0.59，1.21）和0.44（95%置信区间：0.26，0.62）。在BKMR模型中发现了正关节关联，其中6：2Cl-PFESA贡献最大。性别特异性协会存在于单一和多污染物models.ConclusionsLegacy和替代PFASs与葡萄糖稳态标志物呈正相关。6：2Cl-PFESA为主要贡献者。性别特异性协会也被确定。这些结果表明，联合协会和影响修改应考虑在风险评估。然而，建议进一步研究，以加强我们的研究结果，并阐明传统和替代PFAS的作用机制。
BackgroundEpidemiological studies on the associations of legacy per- and polyfluoroalkyl substances (PFASs) and glucose homeostasis remain discordant. Understanding of PFAS alternatives is limited, and few studies have reported joint associations of PFASs and PFAS alternatives.ObjectivesTo investigate associations of novel PFAS alternatives (chlorinated perfluoroalkyl ether sulfonic acids, Cl-PFESAs and perfluorobutanoic acid, PFBA) and two legacy PFASs (Perfluorooctanoic acid, PFOA and perfluorooctane sulfonate, PFOS) with glucose-homeostasis markers and explore joint associations of 13 legacy and alternative PFASs with the selected outcomes.MethodsWe used cross-sectional data of 1,038 adults from the Isomers of C8 Health Project in China. Associations of PFASs and PFAS alternatives with glucose-homeostasis were explored in single-pollutant models using generalized linear models with natural cubic splines for PFASs. Bayesian Kernel Machine Regression (BKMR) models were applied to assess joint associations of exposures and outcomes. Sex-specific analyses were also conducted to evaluate effect modification.ResultsAfter adjusting for confounders, both legacy (PFOA, PFOS) and alternative (Cl-PFESAs and PFBA) PFASs were positively associated with glucose-homeostasis markers in single-pollutant models. For example, in the total study population, estimated changes with 95% confidence intervals (CI) of fasting glucose at the 95th percentile of 6:2Cl-PFESA and PFOS against the thresholds were 0.90 (95% CI: 0.59, 1.21) and 0.44 (95% CI: 0.26, 0.62). Positive joint associations were found in BKMR models with 6:2Cl-PFESA contributing most. Sex-specific associations existed in both single- and multi-pollutant models.ConclusionsLegacy and alternative PFASs were positively associated with glucose-homeostasis markers. 6:2Cl-PFESA was the primary contributor. Sex-specific associations were also identified. These results indicate that joint associations and effect modification should be considered in risk assessment. However, further studies are recommended to strengthen our findings and to elucidate the mechanisms of action of legacy and alternative PFASs.