Cardiovagal modulation and efficacy of aerobic exercise training in obese individuals.
Cardiovagal modulation and efficacy of aerobic exercise training in obese individuals.
复制标题
肥胖个体中有氧运动训练的心脏调节和功效。
DOI：
10.1249/mss.0b013e3182a66411
复制
发表时间：
2014-02
影响因子：
4.1
通讯作者：
Kanaley JA
中科院分区：
文献类型：
--
作者：
Baynard T;Goulopoulou S;Sosnoff RF;Fernhall B;Kanaley JA
即使与肥胖的非糖尿病同龄人相比，2型糖尿病也与运动耐量差和峰值有氧能力（VO 2 peak）相关。运动训练研究已经证明T2 D患者的VO 2峰值有所改善，但这种反应存在很大的变异性。最近的证据表明，心脏自主调节可能是一个重要的因素时，考虑改善有氧能力。确定16周有氧运动计划对伴有和不伴有T2 D的肥胖个体的VO 2峰值的影响，这些肥胖个体在基线时被分类为具有高或低心迷走神经调节（HCVM或LCVM）。肥胖个体（38名女性/19名男性; BMI = 36.1 kg/m2）在空腹状态下进行研究。运动训练4个月（4d/wk，65%VO2peak）前后，坐位3 min，记录心电图。在频谱域中分析ECG记录的HRV。根据第50百分位数的CVM标志物（标准化高频（HFnu））分组，分为高（H）或低（L）CVM。在那些被归类为患有HCVM的患者中，VO 2峰值仅随着运动训练而增加，而与糖尿病状态无关（T2 D：HCVM 20.3至22.5 mL/kg/min，LCVM 24.3至25.0 mL/kg/min;肥胖非糖尿病患者：HCVM 24.5至26.3 mL/kg/min，LCVM 23.1至23.7 mL/kg/min）（p<0.05）。LCVM组的VO 2峰值无变化。体重的变化不能解释HCVM组中VO 2峰值的变化。仅T2 D LCVM组的葡萄糖耐量改善。肥胖个体，无论是否患有T2 D，在运动训练前被归类为相对HCVM时，在16周的有氧训练计划后，有更大的改善VO 2峰值的倾向。
Type 2 diabetes is associated with poor exercise tolerance and peak aerobic capacity (VO2peak) even when compared to obese non-diabetic peers. Exercise training studies have demonstrated improvements in VO2peak among T2D, yet there is a large amount of variability in this response. Recent evidence suggests that cardiac autonomic modulation may be an important factor when considering improvements in aerobic capacity. To determine the effects of a 16 wk aerobic exercise program on VO2peak in obese individuals, with and without T2D, who were classified as having either high or low cardiovagal modulation (HCVM or LCVM) at baseline. Obese individuals (38 women/19 men; BMI = 36.1 kg/m2) were studied in the fasted state. ECG recordings were obtained while seated for 3 min, prior to and after 4 mo of exercise training (4 d/wk, 65% VO2peak). The ECG recording was analyzed for HRV in the spectral domain. Groups were split on a marker of CVM (normalized high frequency (HFnu)) at the 50th percentile, as either high (H) or low (L) CVM. VO2peak only increased with exercise training among those classified as having HCVM, regardless of diabetes status (T2D: HCVM 20.3 to 22.5 mL/kg/min, LCVM 24.3 to 25.0 mL/kg/min; Obese non-diabetics: HCVM 24.5 to 26.3 mL/kg/min, LCVM 23.1 to 23.7 mL/kg/min) (p<0.05). No change in VO2peak was observed for the LCVM group. Changes in weight do not explain the change in VO2peak among the HCVM group. Glucose tolerance only improved among the LCVM group with T2D. Obese individuals, with or without T2D, when classified as having relatively HCVM prior to exercise training, have a greater propensity to improve VO2peak following a 16-week aerobic training program.