Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: The ISRE-mediated route and a novel pathway involving CIITA
Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: The ISRE-mediated route and a novel pathway involving CIITA
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DOI：
10.1016/s1074-7613(00)80348-9
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发表时间：
1997-05-01
期刊：
影响因子：
32.4
通讯作者：
vandenElsen, PJ
中科院分区：
文献类型：
--
作者：
Gobin, SJP;Peijnenburg, A;vandenElsen, PJ
主要组织相容性（MHC）I类表达的组成性和精氨酸诱导水平在转录水平上受到严格控制。在这项研究中，它表明，顺式作用的调节元件网站α的MHC I类启动子是必不可少的IFN γ诱导的反式激活的MHC I类基因表达通过ISRE。此外，发现II类反式激活因子（CIITA），其本身在IFN γ诱导途径的控制下，强烈反式激活MHC I类基因表达并通过位点α发挥其活性。因此，α位点是一个重要的调控元件，介导通过ISRE的IFN γ诱导的经典途径以及涉及CIITA的MHC I类反式激活的新途径。
The constitutive and cytokine-induced levels of major histocompatibility (MHC) class I expression are tightly controlled at the transcriptional level. In this study, it is shown that the cis-acting regulatory element site alpha of the MHC class I promoter is essential for the IFN gamma-induced transactivation of MHC class I gene expression through the ISRE. Moreover, it was discovered that the class II transactivator (CIITA), which is itself under the control of the IFN gamma induction pathway, strongly transactivates MHC class I gene expression and exerts its activity through site alpha. Therefore, site alpha is a crucial regulatory element, mediating the classic route of IFN gamma induction via the ISRE as well as a novel route of MHC class I transactivation involving CIITA.