Prevalence characteristics of cervical human papillomavirus (HPV) genotypes in the Taizhou area, China: a cross-sectional study of 37 967 women from the general population.
Prevalence characteristics of cervical human papillomavirus (HPV) genotypes in the Taizhou area, China: a cross-sectional study of 37 967 women from the general population.
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中国台州地区宫颈人乳头瘤病毒（HPV）基因型流行特征：对37 967名普通人群女性的横断面研究
DOI：
10.1136/bmjopen-2016-014135
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发表时间：
2017-06-09
期刊：
影响因子：
2.9
通讯作者：
Yan WH
中科院分区：
文献类型：
--
作者：
Xu HH;Lin A;Chen YH;Dong SS;Shi WW;Yu JZ;Yan WH
高危型人乳头瘤病毒（hrHPV）在全球范围内高度流行，HPV基因型在地理区域之间存在差异;然而，性传播的HPV可能导致宫颈癌发生。本横断面研究的目的是评估中国东南部台州地区宫颈HPV基因型的流行特征。分析了2012 - 2016年在台州恩泽医疗中心就诊的37967名符合条件的女性（中位年龄：41.6岁;范围：15 - 90岁）的人群样本。使用Luminex 200的GP5 +/bioGP6 +-PCR/MPG检测试剂盒对采集的标本进行HPV基因分型，该检测试剂盒可同时鉴定27种不同的HPV基因型和β-珠蛋白基因（内部对照）。泰州地区人群HPV总体感染率为22.8%，其中高危型HPV、低危型HPV和高危型与低危型混合感染的患病率分别为14.2%、5.7%和3.0%。HPV52、16、58、39、18和56型的检出率分别为19.7%、11.9%、11.5%、7.2%、6.6%和5.6%。HPV多型感染率为5.7%，以52 + 58、16 + 52、16 + 18混合型多见。特定年龄段的HPV患病率呈双峰曲线，第一个峰值出现在21岁以下（41.6%），其次是56 - 60岁年龄段（28.5%）的第二个峰值。门诊组和体检组HPV感染率分别为24.0%和19.5%，两者差异有显著性（P <0.0001）。进一步的数据比较显示，HPV基因型的分布在两组之间有明显差异。这项研究的数据可能对某些地区基于HPV的宫颈癌筛查工作有价值，支持台州地区的当地疫苗接种计划，并促进未来HPV疾病的诊断和治疗。
High-risk human papillomaviruses (hrHPVs) are highly prevalent worldwide, and HPV genotypes differ between geographical regions; however, sexually transmitted HPV may lead to cervical carcinogenesis. The objective of this cross-sectional study was to estimate the prevalence characteristics of cervical HPV genotypes in Taizhou, Southeast China. A population-based sample of 37 967 eligible women (median age: 41.6; range: 15–90 years) visiting the Taizhou ENZE Medical Center in Taizhou (2012–2016) was analysed. HPV genotyping was performed on the collected specimens using a GP5+/bioGP6+-PCR/MPG assay by Luminex 200, which simultaneously identifies 27 different HPV genotypes and the β-globin gene (internal control). The overall HPV infection rate was 22.8% in the Taizhou-based population, and the prevalence of high-risk HPV, low-risk HPV and mixed high-risk and low-risk HPV infection was 14.2%, 5.7% and 3.0%, respectively. The most prevalent genotypes were HPV52 (19.7%), 16 (11.9%), 58 (11.5%), 39 (7.2%), 18 (6.6%) and 56 (5.6%). The rate of multiple-type HPV infection was 5.7% in the whole population, and the HPV52+58, HPV16+52 and HPV16+18 mixed genotypes were most common in women with multiple infections. The age-specific HPV prevalence showed a bimodal curve, with a first peak below the age of 21 years (41.6%), followed by a second peak in the age group of 56–60 years (28.5%). Moreover, the HPV infection rate differed significantly between the outpatient and physical examination groups (24.0% vs 19.5%, p<0.0001). Further data comparisons showed that the distribution of HPV genotypes varied markedly between the two groups. Data from this study could be valuable for HPV-based cervical cancer screening efforts in certain areas, support the local vaccination programme in the Taizhou region and facilitate future diagnosis and treatment of HPV diseases.