Biopsy Sites Suitable for the Diagnosis of Helicobacter pylori Infection and the Assessment of the Extent of Atrophic Gastritis
Biopsy Sites Suitable for the Diagnosis of Helicobacter pylori Infection and the Assessment of the Extent of Atrophic Gastritis
复制标题
适合诊断幽门螺杆菌感染和评估萎缩性胃炎程度的活检部位
DOI：
10.1111/j.1572-0241.1998.166_b.x
复制
发表时间：
1998
影响因子：
9.8
通讯作者：
T. Fujioka
中科院分区：
文献类型：
--
作者：
K. Satoh;K. Kimura;Y. Taniguchi;K. Kihira;T. Takimoto;K. Saifuku;H. Kawata;K. Tokumaru;T. Kojima;M. Seki;K. Ido;T. Fujioka
目的：我们进行这项研究，以确定胃中哪些活检部位适合诊断幽门螺杆菌感染和评估萎缩性胃炎的程度。方法：对 76 例经组织学证实为慢性胃炎的幽门螺杆菌阳性患者进行内镜检查。活检取自以下六个部位：胃中胃窦小弯（部位 1）、胃角（部位 2）、胃中体（部位 3）以及中胃窦大弯（部位 4）、胃角（部位 5）和胃中体（部位 6）。通过内窥镜和组织学评估萎缩性胃炎的程度，并根据其程度将患者分为五组。通过组织学评估幽门螺杆菌状态。根据更新的悉尼系统评估炎症、活动、萎缩和肠化生的组织学严重程度。对每组患者的6个活检部位进行这些项目的等级比较。结果：6部位对于H. pylori感染的诊断最可靠，4部位适合检查胃窦内H. pylori定植状况。部位1、部位3和部位6适合评估萎缩性胃炎的程度。结论：我们的结果表明，为了准确诊断和评估，应从以下四个部位进行活检：胃中窦小弯（部位1）和中体（部位3），以及胃中窦（部位4）和中体（部位6）大弯。
Objectives:We performed this study to determine which biopsy sites in the stomach are suitable for the diagnosis of Helicobacter pylori infection and the assessment of the extent of atrophic gastritis.Methods:Endoscopy was performed in 76 H. pylori-positive patients with histologically confirmed chronic gastritis. Biopsies were taken from the following six sites: the lesser curvatures of the mid-antrum (site 1), the angulus (site 2), the middle body (site 3), and the greater curvatures of the mid-antrum (site 4), the angulus (site 5), and the middle body (site 6) of the stomach. The extent of atrophic gastritis was assessed endoscopically as well as histologically, and patients were classified into five groups according to its extent. H. pylori status was assessed histologically. The histological severity of inflammation, activity, atrophy, and intestinal metaplasia was assessed according to the Updated Sydney System. The grades of these items were compared among the six biopsy sites in each group of patients.Results:Site 6 was most reliable for the diagnosis of H. pylori infection, and site 4 was suitable for examining the status of H. pylori colonization in the antrum. Site 1, site 3, and site 6 were suitable for the assessment of the extent of atrophic gastritis.Conclusions:Our results indicate that for an accurate diagnosis and assessment, biopsies should be taken from the following four sites: the lesser curvatures of the mid-antrum (site 1) and middle body (site 3), and the greater curvatures of the mid-antrum (site 4) and middle body (site 6) of the stomach.
DOI：
--
发表时间：
1988-05
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
P. Correa
通讯作者：
P. Correa