Prognostic value of transient and sustained increase in in-hospital creatinine on outcomes of patients admitted with acute coronary syndrome
Prognostic value of transient and sustained increase in in-hospital creatinine on outcomes of patients admitted with acute coronary syndrome
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DOI：
10.1016/j.amjcard.2006.10.058
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发表时间：
2007-04-01
影响因子：
2.8
通讯作者：
Froehlich, James B.
中科院分区：
文献类型：
--
作者：
Latchamsetty, Rakesh;Fang, Jianming;Froehlich, James B.
肾功能不全或入院时肌酐水平升高与急性冠脉综合征（ACS）患者预后不良相关。本研究旨在确定住院期间肾功能恶化（无论是短暂的还是持续的）是否是ACS患者6个月死亡率的独立危险因素。回顾性分析了2000年6月至2003年5月期间收治的1,417例ACS患者。患者分为3组。第I组包括住院期间肌酐升高0.5 mg/dl，出院时消退的患者。III组包括肌酐升高>0.5 mg/dl且未消退的患者。主要终点是6个月内任何原因导致的死亡率。第II组和第III组患者的6个月死亡率较高（分别为27%和23%;均为P <0.05）。
A history of renal insufficiency or increased creatinine level on admission is associated with poor outcomes in patients with acute coronary syndrome (ACS). This study sought to determine whether in-hospital worsening of renal function, either transient or sustained, is an independent risk factor for 6-month mortality in patients admitted with ACS. A total of 1,417 patients admitted with ACS from June 2000 to May 2003 were reviewed. Patients were classified into 3 groups. Group I included patients with an increase in creatinine during hospitalization of 0.5 mg/dl that resolved by discharge. Group III included patients with an increase in creatinine of >0.5 mg/dl that did not resolve. The primary end point was 6-month mortality from any cause. Patients in groups II and III had higher 6-month mortality rates (27% and 23%, respectively; both p