Lower birth weight is associated with alterations in dietary intake in adolescents independent of genetic factors: A twin study
Lower birth weight is associated with alterations in dietary intake in adolescents independent of genetic factors: A twin study
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DOI：
10.1016/j.clnu.2015.10.012
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发表时间：
2017-02-01
影响因子：
6.3
通讯作者：
Boomsma, Dorret I.
中科院分区：
文献类型：
--
作者：
Doornweerd, Stieneke;IJzerman, Richard G.;Boomsma, Dorret I.
背景和目标：出生体重较低与心血管和代谢疾病的风险增加有关。这些关联至少可以部分地通过晚年饮食摄入的改变来解释。本研究的目的是探讨低出生体重是否与以后生活中膳食摄入量的变化有关，以及这种关联是否是由于宫内环境或遗传因素造成的。 方法：在这项观察性研究中，对 78 名双卵 (DZ) 和 94 名同卵 (MZ) 青少年同性双胞胎受试者的出生体重和膳食摄入量进行了调查。出生体重是从母亲那里获得的。膳食摄入量通过两天的饮食记录进行评估。结果：在整个双胞胎组中，调整当前体重后，较低的出生体重与较高的饱和脂肪摄入量相关（出生体重每增加一公斤，占总能量摄入量 (E%) 的 1.2%，P < 0.01）。所有双胞胎的配对内分析表明，与出生体重较高的双胞胎相比，出生体重较低的双胞胎的总能量摄入量高出 115 kcal，饱和脂肪摄入量高出 0.7 E%（P < 0.05）。调整当前体重差异后，出生体重的配对内差异与能量摄入差异和饱和脂肪摄入差异呈负相关（分别为 P = 0.07 和 P < 0.05）。出生体重的配对内差异与膳食纤维摄入量的配对内差异呈正相关（P < 0.05）。 DZ 和 MZ 双胞胎的这些配对内差异和关联是相似的（差异 P > 0.6）。结论：较低的出生体重与双胞胎中较高的能量和饱和脂肪摄入量有关，并且这些关联与接合性无关，表明出生体重与晚年饮食摄入变化之间的关联是由子宫内环境而不是遗传因素来解释的。 (C) 2015 Elsevier Ltd 和欧洲临床营养与代谢学会。版权所有。
Background & aims: Lower birth weight is associated with an increased risk of cardiovascular and metabolic disease. These associations may, at least in part, be explained by alterations in dietary intake in later life. The aim of this study is to examine whether lower birth weight is associated with alterations in dietary intake in later life, and whether this association is due to intrauterine environmental or genetic factors.Methods: In this observational study birth weight and dietary intake were investigated in 78 dizygotic (DZ) and 94 monozygotic (MZ) adolescent same-sex twin subjects. Birth weight was obtained from the mothers. Dietary intake was assessed by two-day dietary records.Results: In the total group of twins, lower birth weight was associated with higher intake of saturated fat after adjustment for current weight (1.2 per cent of total energy intake (E%) per kg increase in birth weight, P < 0.01). Intra-pair analysis in all twin pairs demonstrated that twins with the lower birth weight had a 115 kcal higher total energy intake and a 0.7 E% higher saturated fat intake compared to their co-twins with the higher birth weight (P < 0.05). Intra-pair differences in birth weight were negatively associated with differences in energy intake and differences in intake of saturated fat after adjustment for differences in current weight (P = 0.07 and P < 0.05, respectively). Intra-pair differences in birth weight were positively associated with intra-pair differences in intake of dietary fibres (P < 0.05). These intra-pair differences and associations were similar for DZ and MZ twins (P for difference > 0.6).Conclusions: Lower birth weight was related with higher intake of energy and saturated fat within twin pairs, and these associations were independent of zygosity, suggesting that the association between birth weight and alterations in dietary intake in later life is explained by intrauterine environmental rather than genetic factors. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.