Physical Microenvironment-Based Inducible Scaffold for Stem Cell Differentiation and Tendon Regeneration
Physical Microenvironment-Based Inducible Scaffold for Stem Cell Differentiation and Tendon Regeneration
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基于物理微环境的干细胞分化和肌腱再生诱导支架
DOI：
10.1089/ten.teb.2018.0018
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Chen Xiao
中科院分区：
文献类型：
--
作者：
Zhang Hong;Liu Meng Fei;Liu Ri Chun;Shen Wei Liang;Yin Zi;Chen Xiao
肌腱损伤是常见的肌肉骨骼系统疾病，但肌腱的再生能力差。为了解决这个问题，肌腱组织工程提供了潜在的战略，为未来的治疗。肌腱组织工程中，机械力和表面形貌等物理微环境因素对调节干细胞命运，提高种子细胞的分化效率起着至关重要的作用。各种可诱导支架已被广泛探索用于肌腱再生，并且支架增强修饰已被广泛研究。在这篇综述中，我们系统地总结了物理微环境对干细胞分化和肌腱再生的影响，我们还提供了一个概述干细胞tenogenic分化的诱导支架。最后，我们提出了一些潜在的基于支架的治疗肌腱损伤，肌腱再生医学提出了一个有趣的观点。
Tendon injuries are common musculoskeletal system disorders, but the tendons have poor regeneration ability. To address this issue, tendon tissue engineering provides potential strategies for future therapeutic treatment. Elements of the physical microenvironment, such as the mechanical force and surface topography, play a vital role in regulating stem cell fate, enhancing the differentiation efficiency of seed cells in tendon tissue engineering. Various inducible scaffolds have been widely explored for tendon regeneration, and scaffold-enhancing modifications have been extensively studied. In this review, we systematically summarize the effects of the physical microenvironment on stem cell differentiation and tendon regeneration; we also provide an overview of the inducible scaffolds for stem cell tenogenic differentiation. Finally, we suggest some potential scaffold-based therapies for tendon injuries, presenting an interesting perspective on tendon regenerative medicine.