Plants, polysaccharides, and the treatment and prevention of neoplasia.
Plants, polysaccharides, and the treatment and prevention of neoplasia.
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DOI：
10.1615/critrevoncog.v11.i34.10
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发表时间：
2000
影响因子：
--
通讯作者：
Ronald P. Pelley;Faith M. Strickland
中科院分区：
文献类型：
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作者：
Ronald P. Pelley;Faith M. Strickland
传统上，植物和真菌是制药行业开发治疗药物的先导化合物的最大来源。目前，蘑菇和植物多糖引起了补充和替代医学的注意，正在进行科学分析和开发，以预防和治疗癌症，两类多糖正在研究中-β-葡聚糖多糖作为生物反应调节剂用于辅助治疗癌症和“寡糖素”相关的寡糖用于预防太阳诱导的皮肤癌。已经在远东进行人体试验的β-葡聚糖，在准备在西方进行临床试验之前，需要进行机理药理学研究和结构功能关系的定义。其他β-葡聚糖，总理自然杀伤细胞抗体依赖细胞介导的细胞毒性正在接近临床试验。寡聚体可下调紫外线辐射损伤的角质形成细胞产生的免疫抑制细胞因子，是预防环境性皮肤癌的有希望的药物。
Plants and Fungi have traditionally been the single largest source of lead compounds for the development of therapeutics by the pharmaceutical industry. Currently mushroom and plant polysaccharides brought to attention by Complementary and Alternative medicine, are undergoing scientific analysis and development to prevent and treat cancer, Two classes of saccharides are under investigation-beta glucan polysaccharides as biological response modifiers for the adjuvant treatment of cancer and "Oligosaccharin"-related oligosaccharides for the prevention of sun-induced skin cancer. Beta glucans already in human trials in the Far East will require mechanistic pharmacologic studies and definition of stucture function relationships before they are ready for clinical trials in the West. Other beta glucans that prime natural killer cells for antibody dependent cell-mediated cytotoxicity are approaching clinical trials. Oligosaccharides that downregulate production of immunosuppressive cytokines by ultraviolet radiation injured keratinocytes are promising agents for the prevention of environmental skin cancer.