Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?
Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?
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DOI：
10.1111/j.1365-2265.2008.03401.x
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发表时间：
2009-06-01
影响因子：
3.2
通讯作者：
Rauz, S.
中科院分区：
文献类型：
--
作者：
Ball, A. K.;Sinclair, A. J.;Rauz, S.
特发性颅内高压（IIH）的病因尚不清楚，但其与肥胖的关系已得到公认。最近的研究已经将肥胖与循环炎症和肥胖相关细胞因子的异常联系起来。本研究的目的是表征脂肪因子和炎性细胞因子在IIH。配对的血清和脑脊液（CSF）标本收集了26例IIH患者，并与62名对照组。使用多重珠粒免疫测定法分析样品的瘦素、白蛋白、脂联素、胰岛素、IL-1 β、IL-6、IL-8（CXCL 8）、TNF α、MCP-1（CCL 2）、肝细胞生长因子、神经生长因子和派-1 JIH患者的CSF瘦素在校正年龄、性别和体重指数（BMI）后显著高于对照组（P = 0.001）。在对照人群中，BMI与血清瘦素（r = 0.34; P = 0.007）和CSF瘦素（r = 0.51; P < 0.0001）相关，但IIH人群的情况并非如此。一旦考虑人体测量因素，IIH患者和对照组的其他炎性细胞因子和脂肪因子的分布没有差异。IIH的特征是CSF瘦素水平显著升高，与BMI无关。我们认为，脑脊液瘦素可能是重要的IIH的病理生理和肥胖IIH可能会发生下丘脑瘦素抵抗的结果。
The aetiology of idiopathic intracranial hypertension (IIH) is not known, but its association with obesity is well-recognized. Recent studies have linked obesity with abnormalities in circulating inflammatory and adiposity related cytokines. The aim of this study was to characterize adipokine and inflammatory cytokine profiles in IIH.Paired serum and cerebrospinal fluid (CSF) specimens were collected from 26 patients with IIH and compared to 62 control subjects. Samples were analysed for leptin, resistin, adiponectin, insulin, IL-1 beta, IL-6, IL-8 (CXCL8), TNF alpha, MCP-1 (CCL2), hepatocyte growth factor, nerve growth factor and PAI-1 using multiplex bead immunoassays.CSF leptin was significantly higher in patients with IIH (P = 0.001) compared to controls after correction for age, gender and body mass index (BMI). In the control population, BMI correlated with serum leptin (r = 0.34; P = 0.007) and CSF leptin (r = 0.51; P < 0.0001), but this was not the case for the IIH population. Profiles of other inflammatory cytokines and adipokines did not differ between IIH patients and controls once anthropometric factors had been accounted for.IIH was characterized by significantly elevated CSF leptin levels which did not correlate with BMI. We suggest that CSF leptin may be important in the pathophysiology of IIH and that obesity in IIH may occur as a result of hypothalamic leptin resistance.