Acetylome analysis reveals the involvement of lysine acetylation in diverse biological processes in Phytophthora sojae.
Acetylome analysis reveals the involvement of lysine acetylation in diverse biological processes in Phytophthora sojae.
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乙酰组分析揭示了赖氨酸乙酰化参与大豆疫霉的多种生物过程。
DOI：
10.1038/srep29897
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发表时间：
2016-07-14
影响因子：
4.6
通讯作者：
Liang W
中科院分区：
文献类型：
--
作者：
Li D;Lv B;Tan L;Yang Q;Liang W
赖氨酸乙酰化是一种动态的、高度保守的翻译后修饰，在真核生物和原核生物细胞代谢的几乎每个方面都起着重要的调节作用。大豆疫霉（Phytophthora sojae）因其巨大的经济影响而成为最重要的植物病原菌之一。然而，迄今为止，对该疫霉中赖氨酸乙酰化的功能知之甚少。在这里，我们对大豆进行了赖氨酸乙酰酶的分析。总共鉴定了1150个蛋白质中的2197个赖氨酸乙酰化位点。修饰后的蛋白质参与多种生物过程，并定位于多个细胞区室。重要的是，研究人员发现7个参与大豆豆载菌致病性或分泌途径的蛋白被乙酰化。这些数据提供了大豆大豆乙酰化酶的第一个全面视图，并为植物病原体赖氨酸乙酰化功能分析提供了重要资源。
Lysine acetylation is a dynamic and highly conserved post-translational modification that plays an important regulatory role in almost every aspects of cell metabolism in both eukaryotes and prokaryotes. Phytophthora sojae is one of the most important plant pathogens due to its huge economic impact. However, to date, little is known about the functions of lysine acetylation in this Phytopthora. Here, we conducted a lysine acetylome in P. sojae. Overall, 2197 lysine acetylation sites in 1150 proteins were identified. The modified proteins are involved in diverse biological processes and are localized to multiple cellular compartments. Importantly, 7 proteins involved in the pathogenicity or the secretion pathway of P. sojae were found to be acetylated. These data provide the first comprehensive view of the acetylome of P. sojae and serve as an important resource for functional analysis of lysine acetylation in plant pathogens.