Quantitative 2D Magnetorelaxometry Imaging of Magnetic Nanoparticles Using Optically Pumped Magnetometers
Quantitative 2D Magnetorelaxometry Imaging of Magnetic Nanoparticles Using Optically Pumped Magnetometers
复制标题
DOI：
10.3390/s20030753
复制
发表时间：
2020-02-01
期刊：
影响因子：
3.9
通讯作者：
Baumgarten, Daniel
中科院分区：
文献类型：
--
作者：
Jaufenthaler, Aaron;Schier, Peter;Baumgarten, Daniel
对于利用磁性纳米颗粒(MNP)的物理性质的生物磁学应用，例如磁热疗，关于MNP的定量空间分布的知识是至关重要的，这可以通过磁弛豫(MRX)成像来提取。在本文中，我们介绍了利用光泵磁强计对磁共振仪进行的MNP的量化、定量一维重建和定量2D成像。在强调商业上可用于MRXI的光泵磁强计(OPM)的潜力的同时，我们讨论了所使用的OPM目前的局限性。我们证明，在我们的OPM设置下，可以精确地定量MNP，铁量可以降到大约6微克，这是很容易改进的。利用一维重建装置，可以高精度、高精度地定量重建点状和复杂的MNP模型。我们表明，使用我们开发的2D MRX成像设备，其尺寸为12厘米乘8厘米，可以精确和准确地重建具有临床相关铁浓度的点状MNP分布。我们的2D设置有可能很容易地扩展到层析样式(因此是切片选择性的)3D扫描仪，通过向模体添加机械轴。
For biomagnetical applications exploiting physical properties of magnetic nanoparticles (MNP), e.g., magnetic hyperthermia, knowledge about the quantitative spatial MNP distribution is crucial, which can be extracted by magnetorelaxometry (MRX) imaging. In this paper, we present quantification, quantitative 1D reconstruction, and quantitative 2D imaging of MNP by exploiting optically pumped magnetometers for MRX. While highlighting the potential of commercially available optically pumped magnetometers (OPM) for MRXI, we discuss current limitations of the used OPM. We show, that with our OPM setup, MNP can be precisely quantified with iron amounts down to approximate to 6 mu g, which can be improved easily. With a 1D-reconstruction setup, point-like and complex MNP phantoms can be reconstructed quantitatively with high precision and accuracy. We show that with our developed 2D MRX imaging setup, which measures 12 cm by 8 cm, point-like MNP distributions with clinically relevant iron concentrations can be reconstructed precisely and accurately. Our 2D setup has the potential to be easily extended to a tomography styled (and thus slice-selective) 3D scanner, by adding a mechanical axis to the phantom.