Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel.
Serum IgG antibody response to the protective antigen (PA) of Bacillus anthracis induced by anthrax vaccine adsorbed (AVA) among U.S. military personnel.
复制标题
美国军人对吸附炭疽疫苗（AVA）诱导的炭疽杆菌保护性抗原（PA）的血清 IgG 抗体反应。
DOI：
10.1016/j.vaccine.2007.11.085
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发表时间：
2008
期刊：
影响因子：
5.5
通讯作者：
Taylor,DavidN
中科院分区：
文献类型：
--
作者：
Singer,DarrellE;Schneerson,Rachel;Bautista,ChristianT;Rubertone,MarkV;Robbins,JohnB;Taylor,DavidN
The seroconversion rates and geometric mean concentrations (GMC) of IgG anti-PA for stored sera from U.S. military personnel immunized 3, 4, and 6 times with the U.S. licensed anthrax vaccine adsorbed were studied. Anti-PA IgG concentrations were measured by ELISA. All 246 vaccinees had low but detectable pre-immunization anti-PA IgG (GMC 1.83μg/mL). Three doses elicited a GMC of 59.92μg/mL and a seroconversion rate of 85.3%, four doses elicited a GMC of 157.44μg/mL and 67.9% and the sixth of 276.95μg/mL and 45.5%, respectively. The forth dose elicited 100% seroconversion compared to the pre-immunization level. These results should facilitate comparison between different immunization schedules and new vaccines.
