Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes
Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes
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DOI：
10.1016/j.tet.2006.04.025
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发表时间：
2006-06-26
期刊：
影响因子：
2.1
通讯作者：
Porco, John A., Jr.
中科院分区：
文献类型：
--
作者：
Gerard, Baudouin;Ryan, Jamie;Porco, John A., Jr.
在Cu（CH_3CN）（4）PF_6催化剂、N，N，N ′-三甲基乙二胺配体、分子氧和4-甲氧基吗啉N-氧化物（NMO）共氧化剂存在下，伯、仲和芳香叠氮化合物与过量的炔发生1，3偶极环加成反应，得到1，4，5-三取代-1，2，3-三唑。(c)2006爱思唯尔有限公司版权所有。
Primary, secondary, and aromatic azides undergo 1,3 dipolar cycloaddition-coupling with an excess of alkyne in the presence of Cu(CH3CN)(4)PF6 as catalyst, N,N,N'-trimethylethylenediamine as ligand, molecular oxygen, and 4-methoxymorpholine N-oxide (NMO) as co-oxidant to afford 1,4,5-trisubstituted-1,2,3-triazoles. (c) 2006 Elsevier Ltd. All-rights reserved.