Discrete visual defects in pearl mutant mice.
Discrete visual defects in pearl mutant mice.
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DOI：
10.1126/science.6600521
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发表时间：
1983-03
期刊：
影响因子：
56.9
通讯作者：
G. Balkema;N. Mangini;L. Pinto
中科院分区：
文献类型：
--
作者：
G. Balkema;N. Mangini;L. Pinto
突变小鼠珍珠，其特点是色素减退，有一个特定的功能缺陷的感觉系统-视网膜。完整的珍珠鼠在黑暗适应条件下的敏感性降低。通过用碳酸氢盐缓冲的林格溶液隔离和灌注视网膜恢复正常的敏感性，这表明珍珠突变的视网膜表达取决于可扩散的物质。珍珠表型被描述为人类先天性静止性夜盲症的可能模型。
The mutant mouse pearl, characterized by its hypopigmentation, has a specific functional defect in a sensory system--the retina. The intact pearl mouse has reduced sensitivity in the dark-adapted condition. Normal sensitivity is restored by isolation and superfusion of the retina with bicarbonate-buffered Ringer solution, suggesting that the retinal expression of the pearl mutation depends on a diffusible substance. The pearl phenotype is described as a possible model for human congenital stationary night blindness.