Mathematical models of cell motility
Mathematical models of cell motility
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DOI：
10.1007/s12013-007-0045-2
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发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
McHugh, P. E.
中科院分区：
文献类型：
--
作者：
Flaherty, Brendan;McGarry, J. P.;McHugh, P. E.
细胞运动是我们身体的创造，运作和维护中必不可少的生物学行为。发展阐明细胞运动的数学模型将大大促进我们对这一基本生物过程的理解。有了精确的模型，就有可能探索同一事件的许多排列，并简明地研究它们的结果。虽然细胞运动的实验研究已经取得了很大的进展，但现在它在某种程度上已经落在数学模型上，在未来的发展中发挥主导作用。其明显的原因是细胞运动的复杂性。利用当今计算机的处理能力将使研究人员能够运行复杂的生物物理和生物化学场景，而没有与体外研究相关的固有困难和时间。在取得任何重大进展之前，细胞运动的基础必须得到明确的定义。没有这一点，复杂的数学模型将受到其固有的猜想的阻碍。这篇评论将着眼于当前的细胞运动的数学调查，探讨这种工作背后的推理，并得出结论，如何最好地推进这一有趣和具有挑战性的研究领域。
Cell motility is an essential biological action in the creation, operation and maintenance of our bodies. Developing mathematical models elucidating cell motility will greatly advance our understanding of this fundamental biological process. With accurate models it is possible to explore many permutations of the same event and concisely investigate their outcome. While great advancements have been made in experimental studies of cell motility, it now has somewhat fallen on mathematical models to taking a leading role in future developments. The obvious reason for this is the complexity of cell motility. Employing the processing power of today's computers will give researches the ability to run complex biophysical and biochemical scenarios, without the inherent difficulty and time associated with in vitro investigations. Before any great advancement can be made, the basics of cell motility will have to be well-defined. Without this, complicated mathematical models will be hindered by their inherent conjecture. This review will look at cur-rent mathematical investigations of cell motility, explore the reasoning behind such work and conclude with how best to advance this interesting and challenging research area.