The organization of the human cerebellum estimated by intrinsic functional connectivity
The organization of the human cerebellum estimated by intrinsic functional connectivity
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DOI：
10.1152/jn.00339.2011
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发表时间：
2011-11-01
影响因子：
2.5
通讯作者：
Yeo, B. T. Thomas
中科院分区：
文献类型：
--
作者：
Buckner, Randy L.;Krienen, Fenna M.;Yeo, B. T. Thomas
Buckner RL，Krienen FM，Castellanos A，迪亚兹JC，Yeo BT.人类小脑的组织由内在功能连接估计。J Neurophysiol 106：2322-2345，2011.首次发表于2011年7月27日; doi：10.1152/jn.00339.2011.-大脑皮层通过多突触回路与小脑沟通。小脑的不同区域连接到不同的大脑区域，形成复杂的地形。在这项研究中，我们探讨了组织的小脑神经回路在人类使用静息态功能连接磁共振成像（fcMRI）。来自1,000名受试者的数据是使用小脑的非线性变形结合大脑皮层的基于表面的对齐进行登记的。脚，手，和舌头的代表性本地化的主题进行运动。从放置在运动体表征的不同部分的种子区域得到的fcMRI图在前叶产生了预期的躯体运动地形图的倒置图，在后叶产生了直立图。接下来，我们绘制了完整的地形图的小脑通过估计的主要大脑目标在小脑中的每个点的发现样本中的500名受试者和复制的地形在500名独立的受试者。人类小脑的大部分映射到关联区域。对17个不同的大脑网络的定量分析显示，小脑专用于每个网络的范围与大脑中网络的范围成比例，只有少数例外，包括初级视觉皮层，它在小脑中没有代表。与躯体运动表征一样，小脑与联合皮层相连的区域也有独立的前部和后部表征，它们的取向是彼此的镜像。这些有序的表征表明，小脑至少拥有两个大的、全大脑的同伦地图，可能还有一个较小的第三个地图。
Buckner RL, Krienen FM, Castellanos A, Diaz JC, Yeo BT. The organization of the human cerebellum estimated by intrinsic functional connectivity. J Neurophysiol 106: 2322-2345, 2011. First published July 27, 2011; doi:10.1152/jn.00339.2011.-The cerebral cortex communicates with the cerebellum via polysynaptic circuits. Separate regions of the cerebellum are connected to distinct cerebral areas, forming a complex topography. In this study we explored the organization of cerebrocerebellar circuits in the human using resting-state functional connectivity MRI (fcMRI). Data from 1,000 subjects were registered using nonlinear deformation of the cerebellum in combination with surface-based alignment of the cerebral cortex. The foot, hand, and tongue representations were localized in subjects performing movements. fcMRI maps derived from seed regions placed in different parts of the motor body representation yielded the expected inverted map of somatomotor topography in the anterior lobe and the upright map in the posterior lobe. Next, we mapped the complete topography of the cerebellum by estimating the principal cerebral target for each point in the cerebellum in a discovery sample of 500 subjects and replicated the topography in 500 independent subjects. The majority of the human cerebellum maps to association areas. Quantitative analysis of 17 distinct cerebral networks revealed that the extent of the cerebellum dedicated to each network is proportional to the network's extent in the cerebrum with a few exceptions, including primary visual cortex, which is not represented in the cerebellum. Like somatomotor representations, cerebellar regions linked to association cortex have separate anterior and posterior representations that are oriented as mirror images of one another. The orderly topography of the representations suggests that the cerebellum possesses at least two large, homotopic maps of the full cerebrum and possibly a smaller third map.