White Matter Disruptions in Adolescents Exposed to Childhood Maltreatment and Vulnerability to Psychopathology
White Matter Disruptions in Adolescents Exposed to Childhood Maltreatment and Vulnerability to Psychopathology
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DOI：
10.1038/npp.2012.133
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发表时间：
2012-11-01
影响因子：
7.6
通讯作者：
Rao, Uma
中科院分区：
文献类型：
--
作者：
Huang, Hao;Gundapuneedi, Tejasvi;Rao, Uma
已知儿童期虐待会对行为、认知和社会功能产生长期的损害，但其潜在机制尚不清楚。更好地了解其内在机制将有助于制定有效的预防干预措施。19名青少年志愿者没有精神疾病的个人历史，但谁暴露于虐待儿童时期，和13名青少年志愿者没有个人或家族史的精神疾病（对照组）进行扩散张量成像（DTI）的研究。然后，以6个月的间隔对参与者进行长达5年的纵向随访，以确定情绪和物质使用障碍的发作。研究了基线DTI扫描获得的各向异性分数（FA）值与随访时精神病理学之间的相关性。基线时，与对照组相比，暴露于儿童期虐待的青少年在左右上级纵束、投射到海马的右扣带束、左下额枕束和胼胝体压部的FA值显著降低。与未患抑郁症的青少年相比，随访时患抑郁症的青少年在上级纵束和右侧扣带回-海马投射的FA值显著降低。青少年谁开发的物质使用障碍在随访期间有显着较低的FA值在右侧扣带-海马投射比他们的同行没有障碍。这些初步结果表明，在儿童期遭受虐待的青少年中观察到的白色物质中断可能与精神病理学的脆弱性增加有关，特别是抑郁症和物质使用障碍。Neuropsychopharmacology（2012）37，2693-2701; doi：10.1038/npp.2012.133; 2012年8月1日在线发表
Childhood maltreatment has been known to produce long- lasting impairments in behavioral, cognitive and social functioning, but their underlying mechanisms are not well- understood. A better understanding of their underlying mechanisms will aid in developing effective preventive interventions. Nineteen adolescent volunteers with no personal history of a psychiatric illness, but who were exposed to maltreatment during childhood, and 13 adolescent volunteers with no personal or family history of a psychiatric disorder (controls) underwent diffusion tensor imaging (DTI) studies. The participants were then followed longitudinally at 6-month intervals for up to 5 years to determine the onset of mood and substance use disorders. The associations among fractional anisotropy (FA) values obtained from the DTI scans at baseline and psychopathology at follow-up were examined. At baseline, adolescents exposed to childhood maltreatment had significantly lower FA values in the left and right superior longitudinal fasciculi, right cingulum bundle projecting to the hippocampus, left inferior fronto-occipital fasciculus, and splenium of the corpus callosum compared with controls. Adolescents who developed major depressive disorder at follow-up had significantly lower FA values in the superior longitudinal fasciculi and the right cingulum-hippocampal projection compared with their counterparts who did not develop the illness. Adolescents who developed substance use disorder during follow-up had significantly lower FA values in the right cingulum-hippocampal projection than their counterparts without the disorder. These preliminary results suggest that white matter disruptions observed in adolescents exposed to childhood maltreatment may be associated with increased vulnerability to psychopathology, specifically depressive and substance use disorders. Neuropsychopharmacology (2012) 37, 2693-2701; doi:10.1038/npp.2012.133; published online 1 August 2012