Autonomic control of blood pressure and heart rate in obese hypertensive dogs.
Autonomic control of blood pressure and heart rate in obese hypertensive dogs.
复制标题
肥胖高血压犬血压和心率的自主控制。
DOI：
10.1152/ajpregu.1996.270.3.r541
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
West,DB
中科院分区：
文献类型：
--
作者：
Truett,AA;Borne,AT;Poincot,MA;West,DB
在高脂肪过度喂养方案之前和之后，在9只狗中评价了心血管功能的自主控制。体重随着过度喂养而显著增加（从19.8 +/- 0.9至29.5 +/- 2.1 kg; P < 0.01）。平均动脉压（MAP）从94.6 +/- 2.1增加到105.5 +/- 3.7 mmHg（P < 0.05），心率（HR）从94.8 +/- 3.5增加到112.3 +/- 5.6次/分（P < 0.01）。在用氯异达明阻断神经节后，评价MAP和HR对甲氧胺（α-激动剂）或异丙肾上腺素（β-激动剂）的剂量反应。肥胖犬对甲氧胺的MAP峰值反应减弱。HR对异丙肾上腺素的反应在瘦犬和肥胖犬之间没有差异。在普萘洛尔存在下，阿托品使瘦犬的HR从80.8 +/- 7增加到202.8 +/- 8.9次/分钟，使肥胖犬的HR从113.8 +/- 12.1增加到131.7 +/- 18.2。这些数据表明，在肥胖犬中观察到的HR增加可能是由于副交感神经抑制减少，而不是交感神经刺激增加。肥胖高血压犬对甲氧胺的反应迟钝，表明肥胖时交感神经对外周血管阻力的控制发生了改变。
Autonomic control of cardiovascular function was evaluated in nine dogs before and after a high-fat overfeeding regimen. Body weight increased significantly (from 19.8 +/- 0.9 to 29.5 +/- 2.1 kg; P < 0.01) with overfeeding. Mean arterial pressure (MAP) increased from 94.6 +/- 2.1 to 105.5 +/- 3.7 mmHg (P < 0.05), and heart rate (HR) increased from 94.8 +/- 3.5 to 112.3 +/- 5.6 beats/min (P < 0.01). After ganglionic blockade with chlorisondamine, dose response of MAP and HR to methoxamine (alpha-agonist) or isoproterenol (beta-agonist) was evaluated. Peak MAP response to methoxamine was blunted in obese dogs. HR response to isoproterenol was not different between lean and obese dogs. Atropine in the presence of propranolol increased HR from 80.8 +/- 7 to 202.8 +/- 8.9 beats/min in lean dogs and from 113.8 +/- 12.1 to 131.7 +/- 18.2 in obese dogs. These data suggest the increase in HR observed in obese dogs may be due to a decrease in parasympathetic inhibition rather than an increase in sympathetic stimulation. The blunted response to methoxamine in obese hypertensive dogs suggests that the sympathetic control of peripheral vascular resistance is altered in obesity.