Acoustic radiation force impulse under clinical conditions with single infusion of ultrasound contrast agent evoking arrhythmias in rabbit heart
Acoustic radiation force impulse under clinical conditions with single infusion of ultrasound contrast agent evoking arrhythmias in rabbit heart
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临床条件下超声造影剂单次输注引起兔心律失常的声辐射力脉冲
DOI：
10.1007/s10396-021-01085-3
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发表时间：
2021
影响因子：
1.8
通讯作者：
Taniguchi Nobuyuki
中科院分区：
文献类型：
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作者：
Rifu Kazuma;Sasanuma Hideki;Takayama Noriya;Nitta Naotaka;Ogata Yukiyo;Akiyama Iwaki;Taniguchi Nobuyuki
目的：我们之前报道了声辐射力脉冲（ARFI）与全氟丁烷作为超声造影剂（UCA）的联合使用在兔模型中引起的机械指数（MI）为1.8或4.0的心律失常。本研究使用一种可以通过b模式成像传输ARFI的新系统来确定MI < 1.8的心律失常的位置。方法6只雄性日本大白兔在全身麻醉下取仰卧位。使用这个系统，我们将ARFI定位到心脏的确切位置。在UCA注射后2分钟对心脏右心室或左心室进行ARFI暴露，MI为0.9-1.2。结果单次UCA输注时，心肌梗死（MI）低于先前报道的兔心脏sarfi诱发了心动过速波。无UCA的ARFI未观察到心律失常。右心室组比左心室组明显更频繁地观察到收缩期外波，心律失常表现出相反的形状。未见致死性心律失常。结论arfi可用于模拟兔心脏单次UCA输注引起的心动过速波的临床情况。右心室组明显比左心室组对ARFI暴露更敏感，导致心律失常。右心室组和左心室组室性早搏形态发生逆转。使用ARFI的超声从业者应该意识到这种不良反应，即使MI低于先前确定的值1.9。
PurposeWe previously reported that acoustic radiation force impulse (ARFI) with concomitant administration of perfluorobutane as an ultrasound contrast agent (UCA)-induced arrhythmias at a mechanical index (MI) of 1.8 or 4.0 in a rabbit model. The present study identified the location of arrhythmias with a MI < 1.8 using a new system that can transmit ARFI with B-mode imaging.MethodsUnder general anesthesia, six male Japanese white rabbits were placed in a supine position. Using this system, we targeted ARFI to the exact site of the heart. ARFI exposure with MI 0.9–1.2 was performed to the right or left ventricle of the heart 2 min after UCA injection.ResultsARFI with a MI lower than previously reported to rabbit heart evoked extrasystolic waves with single UCA infusion. Arrhythmias were not observed using ARFI without UCA. Extrasystolic waves were observed significantly more frequently in the right ventricle group than in the left ventricle group, with arrhythmias showing reversed shapes. No fatal arrhythmias were observed.ConclusionARFI applied to simulate clinical conditions in rabbit heart evoked extrasystolic waves with single UCA infusion. The right ventricle group was significantly more sensitive to ARFI exposure, resulting in arrhythmias, than the left ventricle group. The shapes of PVCs that occurred in the right ventricle group and the left ventricle group were reversed. Ultrasound practitioners who use ARFI should be aware of this adverse reaction, even if the MI is below the previously determined value of 1.9.