Symptoms in patients with ulcerative colitis in remission are associated with visceral hypersensitivity and mast cell activity
Symptoms in patients with ulcerative colitis in remission are associated with visceral hypersensitivity and mast cell activity
复制标题
溃疡性结肠炎缓解期患者的症状与内脏过敏和肥大细胞活性有关
DOI：
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发表时间：
2011
影响因子：
1.9
通讯作者：
A. Masclee
中科院分区：
文献类型：
--
作者：
E. V. van Hoboken;A. Y. Thijssen;R. Verhaaren;P. P. J. van der Veek;F. Prins;H. Verspaget;A. Masclee
抽象目标。缓解期溃疡性结肠炎(UCR)患者经常报告肠易激综合征(IBS)样症状。最近的研究指出肥大细胞在调节IBS内脏高敏感性中所起的作用。我们推测内脏高敏感症经常出现在UCR患者中，并且与乙状结肠粘膜中肥大细胞的数量和活性有关。材料和方法。研究对象为17名对照组和19名UCR患者。直肠顺应性和直肠知觉由电子恒压仪测量。取乙状结肠活检以量化肥大细胞、脱颗粒肥大细胞和靠近粘膜神经末梢的肥大细胞的数量。结果。与对照组相比，UCR组的内脏剥离显著增加(p<；0.05)。直肠感觉与肠易激综合征样症状呈正相关(r=0.969.0 5；p<；0.0 5)。黏膜肥大细胞数量(每100个隐窝)显著高于对照组：228±20对163±18(p<；0.05)。在UCR患者中，粘膜肥大细胞靠近神经末梢的比例较高(58±4比38±3%，P<0.05)或脱颗粒(40±7比16±4%，P<0.05)。黏膜肥大细胞数量与痛觉之间存在显著但微弱的相关性(r=0.32；p<；0.05)。结论。在UCR患者中，直肠高敏感性与粘膜肥大细胞的存在和激活以及IBS样症状有关。
Abstract Objective. Patients with ulcerative colitis in remission (UCR) frequently report irritable bowel syndrome (IBS)-like symptoms. Recent studies have pointed to the role of mast cells in mediating visceral hypersensitivity in IBS. We hypothesized that visceral hypersensitivity is frequently present in patients with UCR and is related to the quantity and activity of mast cells in the sigmoid mucosa. Material and methods. A group of 17 controls and 19 patients with UCR were studied. Rectal compliance and perception were measured by electronic barostat. Sigmoid biopsies were taken to quantify the amount of mast cells, degranulating mast cells and mast cells in close proximity to mucosal nerve endings. Results. Visceroperception significantly increased in UCR (p < 0.05) versus controls. Rectal perception correlated positively with IBS-like symptoms in UCR (r = 0.969; p < 0.05). The amount of mucosal mast cells (per 100 crypts) was significantly increased in UCR versus controls: 228 ± 20 versus 163 ± 18 (p < 0.05). In the UCR patients a higher percentage of mucosal mast cells was in close proximity to nerve endings (58 ± 4 vs. 38 ± 3% in controls; p < 0.05) or was degranulating (40 ± 7 vs. 16 ± 4% in controls; p < 0.05). There was a significant but weak correlation between quantity of mucosal mast cells and pain perception (r = 0.32; p < 0.05). Conclusion. Rectal hypersensitivity is associated with mucosal presence and activation of mast cells and with IBS-like symptoms in patients with UCR.
影响因子：
29.4
作者：
Barbara, Giovanni;Wang, Bingxian;Corinaldesi, Roberto
通讯作者：
Corinaldesi, Roberto
影响因子：
29.4
作者：
Barbara, G;Stanghellini, V;Corinalidesi, R
通讯作者：
Corinalidesi, R
影响因子：
2.6
作者：
E. Szigethy;L. McLafferty;A. Goyal
通讯作者：
E. Szigethy;L. McLafferty;A. Goyal