Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo
Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo
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DOI：
10.1038/nn887
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发表时间：
2002-08-01
影响因子：
25
通讯作者：
Buzsáki, G
中科院分区：
文献类型：
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作者：
Henze, DA;Wittner, L;Buzsáki, G
神经元信息的处理依赖于单个细胞的解剖连接性和细胞特性之间的相互作用。我们研究了这些计算构建模块如何在完整的大鼠海马中一起工作。齿状颗粒细胞的单棘波，细胞内控制，一般未能放电或中间神经元或CA3锥体细胞。相反，尖峰序列有效地放电两种CA3细胞类型。增加颗粒细胞的放电速率增加其靶神经元的放电概率，并减少颗粒细胞列车的发病和诱发的突触后靶点放电之间的延迟。因此，我们得出结论，颗粒细胞CA3突触是“条件引爆器”，依赖于颗粒细胞的放电模式。此外，我们认为，在单个颗粒细胞的信息被转换成一个时间延迟代码在目标CA3锥体细胞和中间神经元。这些数据证明了中枢神经系统的神经回路是如何处理信息的。
Processing of neuronal information depends on interactions between the anatomical connectivity and cellular properties of single cells. We examined how these computational building blocks work together in the intact rat hippocampus. Single spikes in dentate granule cells, controlled intracellularly, generally failed to discharge either interneurons or CA3 pyramidal cells. In contrast, trains of spikes effectively discharged both CA3 cell types. Increasing the discharge rate of the granule cell increased the discharge probability of its target neuron and decreased the delay between the onset of a granule cell train and evoked firing in postsynaptic targets. Thus, we conclude that the granule cell to CA3 synapses are 'conditional detonators,' dependent on granule cell firing pattern. In addition, we suggest that information in single granule cells is converted into a temporal delay code in target CA3 pyramidal cells and interneurons. These data demonstrate how a neural circuit of the CNS may process information.