Regional and postnatal heterogeneity of activity-dependent long-term changes in synaptic efficacy in the dorsal striatum
Regional and postnatal heterogeneity of activity-dependent long-term changes in synaptic efficacy in the dorsal striatum
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DOI：
10.1152/jn.2000.84.3.1422
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发表时间：
2000-09-01
影响因子：
2.5
通讯作者：
Lovinger, DM
中科院分区：
文献类型：
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作者：
Partridge, JG;Tang, KC;Lovinger, DM
兴奋性纹状体突触的高频激活产生突触功效的持久变化，这可能有助于运动和认知功能。虽然一些机制负责诱导长时程增强（LTP）和长时程抑制（LTD）的兴奋性突触反应在纹状体突触的特点，少得多的是已知的因素，在这个大脑区域的突触可塑性的方向。在这里，我们报告异质性的活动依赖性变化的方向突触强度的发展中大鼠纹状体的亚区域。在背外侧区的前纹状体的神经元往往表达LTD后，高频传入刺激（HFS）在切片年龄P15-P34的动物。然而，背外侧纹状体从P12-P14的HFS引起的N-甲基-D-天冬氨酸（NMDA）受体依赖的形式的LTP。突触在背内侧前纹状体表现出的倾向，表达NMDA受体依赖的形式的LTP在整个发展的时间段检查。NMDA受体拮抗剂（+/-）-2-氨基-5-磷酸戊酸（APV）可抑制P12-P15大鼠纹状体诱发兴奋性突触后电位，但对老龄大鼠纹状体无明显影响。纹状体中多种形式的突触可塑性的表达表明，该脑区在某些形式的运动序列和刻板行为的获得或编码中发挥关键作用的机制。
High-frequency activation of excitatory striatal synapses produces lasting changes in synaptic efficacy that may contribute to motor and cognitive functions. While some of the mechanisms responsible for the induction of long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic responses at striatal synapses have been characterized, much less is known about the factors that govern the direction of synaptic plasticity in this brain region. Here we report heterogeneous activity-dependent changes in the direction of synaptic strength in subregions of the developing rat striatum. Neurons in the dorsolateral region of the anterior striatum tended to express LTD after high-frequency afferent stimulation (HFS) in slices from animals aged P15-P34. However, HFS in dorsolateral striatum from P12-P14 elicited an N-methyl-D-aspartate (NMDA) receptor-dependent form of LTP. Synapses in the dorsomedial anterior striatum exhibited a propensity to express an NMDA-receptor dependent form of LTP across the entire developmental time period examined. The NMDA receptor antagonist (+/-)-2-amino-5-phosphopentanoic acid (APV) inhibited evoked excitatory postsynaptic potentials recorded in striatum obtained from P12-P15 rats but had little effect in striatum from older animals. The expression of multiple forms of synaptic plasticity in the striatum suggests mechanisms by which this brain region plays pivotal roles in the acquisition or encoding of some forms of motor sequencing and stereotypical behaviors.