Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy
Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy
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DOI：
10.1002/anie.200461603
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发表时间：
2005-01-01
影响因子：
16.6
通讯作者：
Kataoka, K
中科院分区：
文献类型：
--
作者：
Jang, WD;Nishiyama, N;Kataoka, K
照片整理：通过阴离子树枝状卟啉和聚（乙二醇）聚（L-赖氨酸）嵌段共聚物的静电组装，在水介质中形成聚合物胶束系统（见图）。胶束表现出高光细胞毒性和稳定性。流体动力学尺寸（约 60 nm）使这种聚合物胶束系统适合光动力肿瘤治疗中的静脉注射。（如图所示）。
Photo finish: A polymeric micelle system is formed in aqueous media by electrostatic assembly of an anionic dendrimeric porphyrin and a poly (ethylene glycol) poly (L-lysine) block copolymer (see picture). The micelles exhibit high photocytotoxicity and stability. The hydrodynamic size (ca. 60 nim) makes this polymeric micelle system suitable for intravenous administration in photodynamic tumor therapy.(Figure Presented).