Fetal electrophysiology.
Fetal electrophysiology.
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胎儿电生理学。
DOI：
10.1111/j.1540-8159.2008.01145.x
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Strasburger,JanetteF
中科院分区：
文献类型：
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作者：
Strasburger,JanetteF
在本期《起搏与临床电生理学》中，来自德国波鸿格罗内迈尔研究所生物磁学部门的Peter货车Leeuwen及其同事描述了双胞胎妊娠期间，在氟卡尼治疗双胞胎胎儿室上性心动过速期间的系列心率变异性评估和电生理评估。[1]对母亲和双胞胎的药物效应的分析表明，在胎儿文献中，室上性心动过速（SVT）治疗的许多报道中，这种彻底性是罕见的，虽然从表面上看，这篇手稿是一篇写得很好的病例报告，但它对整个心脏电生理学的重要性要大得多。货车Leeuwen证明了使用胎儿心磁图（fMCG）-一种完全被动、安全和无创的工具-检测可能危及生命的心率变异性异常和心脏传导变化的能力。作者进一步分析了药物对妊娠患者自身的影响。在“未受影响”的双胞胎中出现的变化是否仅仅是由于氟卡尼暴露的结果，或者是由于双胞胎妊娠本身的自然并发症，这并不是重点。本报告显示，使用fMCG进行一种强化心脏电生理诊断和护理的可能性，并可能对妊娠结局产生有利影响。
In this issue of Pacing And Clinical Electrophysiology, Peter Van Leeuwen and colleagues from the Department of Biomagnetism, Gronemeyer Institute, Bochum, Germany, describe the serial heart rate variability assessment and electrophysiologic assessment of a twin pregnancy, during flecainide treatment of fetal supraventricular tachycardia in one twin. 1 This analysis of medication effects in the mother and both twins demonstrates a degree of thoroughness uncommon to many accounts of supraventricular tachycardia (SVT) management in the fetal literature.While on the surface this manuscript represents a well-written case report, its importance is much greater to cardiac electrophysiology as a whole. Van Leeuwen demonstrates the ability, using fetal magnetocardiography (fMCG)—a completely passive, safe, and noninvasive tool—to detect potentially life-threatening heart rate variability abnormalities and cardiac conduction changes in a presumably healthy twin fetus. The author further analyzes the drug’s effect in the pregnant patient herself. Whether the changes manifest in the “unaffected” twin occurred solely as the result of flecainide exposure or were due to natural complications of the twin gestation itself is not the point. This report shows the potential that a form of intensive cardiac electrophysiologic diagnostics and care might be possible using fMCG and might favorably impact pregnancy outcome.