SEROTONERGIC AND NORADRENERGIC RECEPTORS IN THE RAT-BRAIN - MODULATION BY CHRONIC EXPOSURE TO OVARIAN HORMONES
SEROTONERGIC AND NORADRENERGIC RECEPTORS IN THE RAT-BRAIN - MODULATION BY CHRONIC EXPOSURE TO OVARIAN HORMONES
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DOI：
10.1016/0024-3205(83)90053-x
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发表时间：
1983-01-01
期刊：
影响因子：
6.1
通讯作者：
MCEWEN, BS
中科院分区：
文献类型：
--
作者：
BIEGON, A;RECHES, A;MCEWEN, BS
去甲肾上腺素能（α 1和β）用雌激素、孕激素或两者联合治疗2周的去卵巢雌性大鼠，测定脑内雌激素能（5 HT 1和5 HT 2）受体。雌激素处理导致5 HT 1和β-羟色胺的数量减少。肾上腺素能受体，伴随着5 HT 2受体的增加。孕酮单独引起5 HT 2受体的较小增加，5 HT 1的类似减少，对去甲肾上腺素能受体没有显著影响。当与雌激素一起给予时，孕酮阻断了雌激素对5 HT 2受体的作用，但不抑制雌激素介导的5 HT 1和β-羟色胺的降低。肾上腺素能受体α 1-肾上腺素能受体不受任何激素治疗范例的影响。β-肾上腺素能受体和5-HT 2受体通常与抗抑郁作用有关，卵巢激素对这两种受体类型的调节可能与[人类]抑郁相关的情感变化有关，如经前紧张和产后抑郁。
Noradrenergic (.alpha.1 and .beta.) and serotonergic (5HT1 and 5HT2) receptors were assayed in the brains of ovariectomized female rats treated for 2 wk with estrogen, progesterone or a combination of both hormones. Estrogen treatment resulted in a decrease in the number of 5HT1 and .beta.-adrenergic receptors, with a concomitant increase in 5HT2 receptors. Progesterone alone caused a smaller increase in 5HT2 receptors, a similar decrease in 5HT1 and had no significant effect on noradrenergic receptors. When given with estrogen, progesterone blocked the estrogen effect on 5HT2 receptors but did not inhibit the estrogen-mediated decrease in 5HT1 and .beta.-adrenergic receptors. .alpha.1-Adrenergic receptors were not affected by any of the hormone treatment paradigms. .beta.-Adrenergic and 5HT2 receptors are often implicated in antidepressant action, and the modulation of these 2 receptor types by ovarian hormones might be relevant to hormone-linked affective changes [in humans] such as premenstrual tension and post-partum depression.