CT spectral parameters and serum tumour markers to differentiate histological types of cancer histology
CT spectral parameters and serum tumour markers to differentiate histological types of cancer histology
复制标题
CT能谱参数和血清肿瘤标志物可区分癌症组织学的组织学类型。
DOI：
10.1016/j.crad.2018.07.104
复制
发表时间：
2018-12-01
影响因子：
2.6
通讯作者：
Jiang, H.
中科院分区：
文献类型：
--
作者：
Jia, Y.;Xiao, X.;Jiang, H.
目的：目的：应用计算机断层扫描（CT）光谱定量参数结合血清肿瘤标志物评价肺癌组织学类型。获得CT光谱定量参数，包括衰减值、光谱曲线斜率（λ）、碘浓度、水浓度和有效原子序数（Zeff）。还获得了肿瘤标志物的血清水平，包括癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）、鳞状细胞癌抗原（SCC-Ag）和细胞角蛋白片段CYFRA21 - 1。比较不同组织学类型肺癌的上述指标。血清肿瘤标志物，CT光谱参数，以及它们的组合的诊断效率进行了计算，通过统计分析。结果：CEA和NSE水平较高，腺癌和神经内分泌肿瘤，分别，而SCC-Ag和CYFRA21 - 1水平较高，鳞状细胞癌。各组间衰减无显著性差异（p> 0.05），而动脉期a、动、静脉期Zeff和IC有显著性差异（p
AIM: To evaluate lung cancer histology type using computed tomography (CT) spectral quantitative parameters combining with serum tumour markers.MATERIALS AND METHODS: Patients with suspicious lung cancer underwent CT spectral imaging and serum tumour markers. CT spectral quantitative parameters including attenuation value, the slope of spectral curve (lambda), iodine concentration, water concentration, and effective atomic number (Zeff) were acquired. Serum levels of tumour markers including carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), squamous cell carcinoma antigen (SCC-Ag), and cytokeratin fragment CYFRA21-1 were also obtained. All the values were compared among different histological types of lung cancer. The diagnostic efficiencies of serum tumour markers, CT spectral parameters, and a combination of them were computed by statistical analysis.RESULTS: CEA and NSE levels were higher in adenocarcinoma and neuroendocrine tumour, respectively, while SCC-Ag and CYFRA21-1 levels were higher in squamous cell cancer. There was no significant difference in attenuation among the groups (p>0.05), whereas a in the arterial phase, and Zeff and IC in both the arterial and venous phases were significantly different among groups (p