ANTICIPATORY ACTIVITY AND ENTRAINMENT OF CIRCADIAN-RHYTHMS IN SYRIAN-HAMSTERS EXPOSED TO RESTRICTED PALATABLE DIETS
ANTICIPATORY ACTIVITY AND ENTRAINMENT OF CIRCADIAN-RHYTHMS IN SYRIAN-HAMSTERS EXPOSED TO RESTRICTED PALATABLE DIETS
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DOI：
10.1152/ajpregu.1992.263.1.r116
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发表时间：
1992-07-01
影响因子：
--
通讯作者：
RUSAK, B
中科院分区：
文献类型：
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作者：
ABE, H;RUSAK, B
在三种情况下记录仓鼠的活动节律：定时喂食有吸引力的食物并自由获取常规食物，限制正常食物摄入量的70%，以及适度剥夺食物并限制时间获取有吸引力的食物。一个有吸引力的饮食给予完整的动物不诱导预期活动或携带，但损伤的视交叉上核（SCN）导致预期活动的发展。在一些完整的动物中，将食物限制在正常摄入量的70%会导致预期成分，而不会影响主要的昼夜节律起搏器。在一些动物中，美味的饮食和食物限制的结合导致了每日喂食时间之前的预期活动，并引起了先前自由运行的昼夜节律的干扰。在实验动物中，SCN的消融并没有消除预期活动，但确实消除了节律的自由运行成分。这些结果表明，仓鼠有一种独立于SCN的机制，可以像大鼠一样预测每天的喂食时间，并且它们可能显示出基于SCN的起搏器对这种喂食时间表的干扰。
Activity rhythms were recorded from hamsters in three conditions: during timed feedings of an attractive diet with free access to regular food, during restriction to 70% of normal food consumption, and during moderate food deprivation with limited temporal access to an attractive diet. An attractive diet given to intact animals did not induce anticipatory activity or entrainment, but damage to the suprachiasmatic nuclei (SCN) led to the development of anticipatory activity. Food restriction to 70% of normal intake led to anticipatory components in some intact animals, without entraining the dominant circadian pacemaker. The combination of a palatable diet and food restriction led to anticipatory activity before the daily feeding times and entrainment of a previously free-running circadian rhythm in some animals. Ablation of the SCN did not eliminate anticipatory activity in experimental animals, but did eliminate the free-running component of the rhythms. These results indicate that hamsters have a mechanism separate from the SCN that can anticipate daily feeding times, as rats do, and that they may show entrainment of the SCN-based pacemaker to such feeding schedules.