Tuberculosis vaccines in the era of Covid-19 - what is taking us so long?

Tuberculosis vaccines in the era of Covid-19 - what is taking us so long?
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DOI:
10.1016/j.ebiom.2022.103993
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发表时间:
2022-05
期刊:
影响因子:
11.1
通讯作者:
McShane, Helen
McShane, Helen
中科院分区:
医学1区
文献类型:
--
作者:
Dockrell, Hazel M.;McShane, Helen

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牛分枝杆菌卡介苗于1921年首次使用,但未能控制结核病(TB)的全球传播。仍然没有新的获得许可的结核病疫苗,尽管有许多积极的研究和疫苗开发流水线,疫苗旨在预防感染、预防疾病或加速结核病治疗。这些疫苗的类型不同,旨在取代卡介苗,或在接种卡介苗后提高免疫力。这一观点讨论了为什么当开发SARS-CoV-2新疫苗如此之快的时候,开发新的结核病疫苗却要花这么长的时间。
The Mycobacterium bovis BCG vaccine was first used in 1921, but has not controlled the global spread of tuberculosis (TB). There are still no new licensed tuberculosis vaccines, although there much active research and a vaccine development pipeline, with vaccines designed to prevent infection, prevent disease, or accelerate TB treatment. These vaccines are of different types, and designed to replace BCG, or to boost immunity following BCG vaccination. This viewpoint discusses why, when it has been possible to develop new vaccines for SARS-CoV-2 so quickly, it is taking so long to develop new tuberculosis vaccines.
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