The maturation of auditory responses in infants and young children: a cross-sectional study from 6 to 59 months.
The maturation of auditory responses in infants and young children: a cross-sectional study from 6 to 59 months.
复制标题
DOI：
10.3389/fnana.2015.00131
复制
发表时间：
2015
影响因子：
2.9
通讯作者：
Roberts TP
中科院分区：
文献类型：
--
作者：
Edgar JC;Murray R;Kuschner ES;Pratt K;Paulson DN;Dell J;Golembski R;Lam P;Bloy L;Gaetz W;Roberts TP
背景资料：了解典型发育中的婴儿和幼儿的听觉皮层反应的成熟程度，对于以后识别有神经发育障碍风险的婴儿的听觉处理异常是必要的。婴儿和幼儿脑磁图（MEG）系统的可用性，现在可以提供接近最佳的评估左右半球的听觉神经磁反应的年轻人群。为了评估一种新的全头婴儿MEG系统的性能，一项横断面研究检查了6至59个月大的儿童左右听觉皮层反应的成熟度。研究方法：呈现1000 Hz（第1和第3块）和500 Hz音调（第2块）的块，同时使用婴儿/幼儿生物磁力计（Artemis 123）记录MEG数据。数据来自29名儿童（11名男性; 6至59个月）。潜伏期测量获得的第一个积极到消极的诱发反应波形复杂的每个半球。潜伏期和年龄协会以及频率和半球潜伏期的差异进行了检查。对于1000 Hz音调，计算可靠性的测量。结果：对于第一个响应-一个响应与“P2 m”地形图-lavonium作为年龄的函数下降。对于第二个响应-一个响应与“N2 m”地形-没有N2 m潜伏期和年龄的关系进行了观察。音调频率的主要效应显示第一个1000 Hz（150 ms）和第二个1000 Hz（148 ms）与500 Hz音调（162 ms）的P2 m反应更早。半球的显著主效应显示第二个1000 Hz（226 ms）与第一个1000 Hz（241 ms）与500 Hz音调（265 ms）的N2 m反应更早。P2 m和N2 m潜伏期的相关系数为：左侧P2 m（0.72，p < 0.001），右侧P2 m（0.84，p < 0.001），左侧N2 m（0.77，p < 0.001），右侧N2 m（0.77，p < 0.01）。结论：强的年龄和潜伏期的关联，对音调频率的敏感性，以及良好的重测信度的研究结果支持的可行性纵向婴儿MEG研究，包括年轻以及老年参与者，以及研究听觉处理异常的婴儿在神经发育障碍的风险。
Background: An understanding of the maturation of auditory cortex responses in typically developing infants and toddlers is needed to later identify auditory processing abnormalities in infants at risk for neurodevelopmental disorders. The availability of infant and young child magnetoencephalography (MEG) systems may now provide near optimal assessment of left and right hemisphere auditory neuromagnetic responses in young populations. To assess the performance of a novel whole-head infant MEG system, a cross-sectional study examined the maturation of left and right auditory cortex responses in children 6- to 59-months of age. Methods: Blocks of 1000 Hz (1st and 3rd blocks) and 500 Hz tones (2nd block) were presented while MEG data were recorded using an infant/young child biomagnetometer (Artemis 123). Data were obtained from 29 children (11 males; 6- to 59-months). Latency measures were obtained for the first positive-to-negative evoked response waveform complex in each hemisphere. Latency and age associations as well as frequency and hemisphere latency differences were examined. For the 1000 Hz tone, measures of reliability were computed. Results: For the first response—a response with a “P2m” topography—latencies decreased as a function of age. For the second response—a response with a “N2m” topography—no N2m latency and age relationships were observed. A main effect of tone frequency showed earlier P2m responses for 1st 1000 Hz (150 ms) and 2nd 1000 Hz (148 ms) vs. 500 Hz tones (162 ms). A significant main effect of hemisphere showed earlier N2m responses for 2nd 1000 Hz (226 ms) vs. 1st 1000 Hz (241 ms) vs. 500 Hz tones (265 ms). P2m and N2m interclass correlation coefficient latency findings were as follows: left P2m (0.72, p < 0.001), right P2m (0.84, p < 0.001), left N2m (0.77, p < 0.001), and right N2m (0.77,p < 0.01). Conclusions: Findings of strong age and latency associations, sensitivity to tone frequency, and good test-retest reliability support the viability of longitudinal infant MEG studies that include younger as well as older participants as well as studies examining auditory processing abnormalities in infants at risk for neurodevelopmental disorders.