Use of human reconstituted epidermis Episkin® for assessment of weak phototoxic potential of chemical compounds
Use of human reconstituted epidermis Episkin® for assessment of weak phototoxic potential of chemical compounds
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使用人体重建表皮 Episkin® 评估化合物的弱光毒性潜力
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
M. Mariani
中科院分区：
文献类型：
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作者：
P. Portes;M. J. Pygmalion;E. Popovic;M. Cottin;M. Mariani
背景/目的：药物光毒性是一种非免疫性炎症性皮肤反应，由局部或全身同时暴露于特定分子和紫外线辐射引起。大多数光毒化合物吸收能量，特别是从UVA光中吸收能量，从而产生活化的衍生物，从而导致细胞损伤。这种类型的不良皮肤反应可以在体外使用人类皮肤模型重现。在这项研究中，我们研究了人重组表皮Episkin®评估弱光毒性化合物如6-甲基香豆素和氧氟沙星的皮肤光毒性的能力，并与强光毒性化合物氯丙嗪和两个阴性对照(十二烷基硫酸钠(十二烷基硫酸钠，十二烷基硫酸钠)，舒异苯宗)进行了比较。
Background/purpose: Drug‐induced phototoxicity is a non‐immunological inflammatory skin reaction, caused by concurrent topical or systemic exposure to a specific molecule and ultraviolet radiation. Most of phototoxic compounds absorb energy particularly from UVA light leading to activated derivatives, which can induce cellular damage. This type of adverse cutaneous response can be reproduced, in vitro, using human skin models. In this study, we investigated the ability of human reconstituted epidermis Episkin® to assess skin phototoxicity of weak phototoxic compounds such as 6‐methylcoumarin and ofloxacin, compared to a strong one, chlorpromazine, and two negative controls (sodium dodecyl sulphate (SDS), sulisobenzone).